| VX2骨肿瘤模型的超声造影和磁共振初步观察 |
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| 引用本文： | 吴蓉,胡兵,姜立新,黄瑛,徐繁华,蒋旭东. VX2骨肿瘤模型的超声造影和磁共振初步观察[J]. 中华医学超声杂志(电子版), 2008, 5(3): 11-13 |
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| 作者姓名： | 吴蓉 胡兵 姜立新 黄瑛 徐繁华 蒋旭东 |
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| 作者单位： | 1. 上海交通大学附属第六人民医院超声医学科,200233
2. 河北省直属机关第一门诊部超声科 |
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| 摘 要： | 目的观察实验兔VX2恶性骨肿瘤模型的超声造影、MRI表现和病理变化，为高强度聚焦超声（HIFU）治疗恶性骨肿瘤影像学随访提供实验模型。方法将VX2肿瘤组织块接种于10只新西兰大白兔胫骨上端干骺端骨髓腔内，3周后进行超声和MRI检查，并进行病理检查。结果10只模型全部接种成功，超声表现为局部骨组织回声消失，胫骨骨皮质破坏，肿瘤内部回声不均匀，彩色多普勒血流成像和彩色多普勒能量图显示肿瘤内彩色血流丰富。注人超声造影剂Sono Vue后，肿瘤明显强化，血流灌注方式呈“快进快退”。磁共振平扫T1WI呈等信号，T2WI呈不均匀高信号，增强后明显强化。病理检查镜下见大片肿瘤细胞。结论兔VX2恶性骨肿瘤模型的建立，可为HIFU治疗恶性骨肿瘤提供较为理想的实验模型，并且为治疗前后的影像学评估提供实验依据。
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| 关 键 词： | 骨肿瘤 兔 动物模型 造影剂 磁共振成像 |
Observation of contrast-enhanced sonography and MRI in an experimental rabbit model with VX2 bone tumor |
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| WU Rong,HU Bing,JIANG Li-xin,HUANG Ying,XU Fan-hua,JIANG Xu-dong. Observation of contrast-enhanced sonography and MRI in an experimental rabbit model with VX2 bone tumor[J]. Chinese Journal of Medical Ultrasound, 2008, 5(3): 11-13 |
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| Authors: | WU Rong HU Bing JIANG Li-xin HUANG Ying XU Fan-hua JIANG Xu-dong |
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| Affiliation: | WU Rong,HU Bing,JIANG Li-xin,HUANG Ying,XU Fan-hua,JIANG Xu-dong. Department of Ultrasound in Medicine,Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Shanghai 200233,China |
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| Abstract: | Objective To observe an experimental rabbit model with VX2 malignant bone tumor in imaging manifestations,MRI and pathological changes. Methods Ten New Zealand white rabbits were inoculated with VX2 tumor in cavitas medullaris of proximal metaph tibia. Three weeks after inoculation,the rabbits underwent ultrasonography and MRI scanning. The imaging findings were observed and analyzed. Results The inoculation was successful in 10 rabbits (100 %). Local bone tissues disappeared on ultrasound,cortical bone of ... |
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| Keywords: | Bone neoplasms Rabbits Animal models Contrast media Magnetic resonance imaging |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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