Modulation of the intestinal flora of mice by treatment with aztreonam and tigemonam. |
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| Authors: | M L van Ogtrop H F Guiot H Mattie E van Strijen B R Sekh R van Furth |
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| Affiliation: | Department of Infectious Diseases, University Hospital, Leiden, The Netherlands. |
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| Abstract: | Oral and parenteral administration of aztreonam and oral administration of tigemonam to conventional mice caused a decrease in the number of aerobic gram-negative rods in the feces. Oral treatment with high doses of aztreonam (greater than or equal to 25 mg/kg/day) and tigemonam (100 mg/kg/day) adversely influenced colonization resistance, whereas oral treatment with lower doses of the monobactams or parenteral treatment with aztreonam did not. |
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