Spirotoamides A and B, novel 6,6-spiroacetal polyketides isolated from a microbial metabolite fraction library |
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Authors: | Nogawa Toshihiko Takahashi Shunji Okano Akiko Kawatani Makoto Uramoto Masakazu Saito Tamio Osada Hiroyuki |
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Institution: | Chemical Biology Core Facility, Chemical Biology Department, RIKEN Advanced Science Institute, Saitama, Japan. |
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Abstract: | Two new 6,6-spiroacetal polyketides, spirotoamides A (1) and B (2), were isolated from a microbial metabolite fraction library of Streptomyces griseochromogenes JC82-1223 by screening of structurally unique compounds based on a search of spectral database. The fraction library was constructed using a systematic separation method to efficiently discover new metabolites from microbial sources such as actinomycetes and fungi. The structures of 1 and 2 were elucidated by 2D-NMR and mass spectrometric measurements. They belong to a class of polyketides, and contain a 6,6-spiroacetal core structure and a carboxamide group. The biosynthetic pathway of 1 and 2 is discussed in the text. |
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