肝纤维化中细胞因子的作用

肝纤维化是继发于各种形式慢性肝损伤之后的组织修复过程中的代偿反应,它也是慢性肝病发展为肝硬化的必经病理过程.各种病因所引起的慢性肝病绝大多数都有肝纤维化,其中25%～加%最终发展为肝硬化乃至肝癌.因此,肝纤维化的发生机制成为目前慢性肝病的研究热点之一.肝纤维化的形成是一个多因素、多细胞参与的复杂过程,涉及多种细胞因子和蛋白成分表达的改变,细胞因子在肝星形细胞的活化、表型改变中扮演重要角色.此文对部分细胞因子在肝纤维化中的作用作一简要综述.

The effect of some cytokines in liver fibrosis

Liver fibrosis is induced by the compensatory react of hepatic tissue renovation after all kinds of chronic hepatic injuries,and is also an essential phase of liver cirrhosis.Many chronic hepatic injuries develop into liver fibrosis,cirrhosis,even hepatocellular carcinoma.Aecordingly,the mechanism of liver fibrosis has beconle an investigative hot spot of chronicliver disease.Liver fibrosis formation is a complex process with multiple factors andmany cells,which includes the changes of many cytokines and express of protein component.Cytokines play a considerable role in hepatic stellate cells activeafion and shape alteration.The research gives a simple summary about the effect of some cytokines in liver fibrosis.