环腺苷酸效应元件结合蛋白在学习记忆中的作用及机制

背景 环腺苷酸效应元件结合蛋白(cAMP response-element binding protein,CREB)是新发现的学习记忆正调控因子.近年来的研究提示CREB可能通过多种途径调控学习记忆. 目的 阐述CREB在学习记忆中的作用及机制,为认知障碍相关疾病的防治提供思路. 内容 阐述CREB的来源、结构及其在学习记忆中的作用.分析其调控学习记忆的相关机制. 趋向 CREB的确切上游调控机制及自身的表达调控需要进一步明确,对其深入研究可为多种认知障碍疾病的防治提供新的靶点与思路.

The role and mechanism of cyclic adenosine monophosphate response-element binding protein in learning and memory

Background The cAMP response-element binding protein(CREB) is one of recently disclosed positive regulating factors of learning and memory.Recent evidences indicate that CREB may regulate learning and memory through multiple pathways.Objective To clarify the role and its relative mechanisms of CREB in regulating learning and memory,thus to provide insight in the preventive and therapeutic strategy for cognitive dysfunction diseases.Content The origination,structure,the role of CREB in regulating learning and memory and its mechanisms were discussed.Trend The exact upstream regulatory mechanism of CREB and its self-regulation need further studies.these studies on CREB might provide new targets and ideas for the prevention and treatment of cognitive disorder diseases.