| CCL8在疾病免疫调节中的作用 |
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| 引用本文： | 周倩,张国龙,王秀丽. CCL8在疾病免疫调节中的作用[J]. 国际免疫学杂志, 2016, 0(3): 250-253. DOI: 10.3760/cma.j.issn.1673-4394.2016.03.011 |
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| 作者姓名： | 周倩 张国龙 王秀丽 |
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| 作者单位： | 200443,上海市皮肤病医院、同济大学医学院光医学研究所 |
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| 基金项目： | 国家自然科学基金面上项目项目资助(81472538)，国家自然科学基金青年项目项目资助(81201222)，上海市自然科学基金重大项目子课题(15411950302)，General Program of National Natural Science Foundation of China(81472538)，Youth Program of National Natural science Foundation of China(81201222)，Major Program sub-project of Natural Science Foundation of Shanghai(15411950302) |
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| 摘 要： | 单核细胞趋化蛋白2 (MCP-2)即CCL8是CC趋化蛋白家族中的一员,可通过与CCR1、CCR2、CCR3和CCR5受体结合,招募单核细胞、T细胞、嗜酸性细胞、嗜碱性细胞、NK细胞和树突状细胞在炎症反应、抗瘤免疫和aGVHD中发挥着重要的免疫调节作用.研究CCL8的一般分子生物学特性及其在疾病免疫调节中作用可以促进对其进一步的研究,因而具有重要意义.
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| 关 键 词： | 免疫 趋化因子 CCL8 |
The role of CCL8 in immune regulation of diseases |
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| Abstract: | Monocyte chemoattractant protein 2 (MCP-2),also named CCL8,is a member of the CC chemokine family and it could attract monocytes,T lymphocytes,eosinophils,and basophils,NK cell and DC cell through recognizing several receptors including CCR1,CCR2,CCR3,CCR5.It play an important role in regulation of immunity in inflammation response,anti-tumor immunity and acute graft versus host disease (aGVHD).It is impostant to makes a summary on the biological characteristics of CCL8 and the development of the role of CCL8 in immune regulation of diseases. |
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| Keywords: | Immunity Chemokine CCL8 |
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