徐州地区铜绿假单胞菌药敏试验结果分析

目的了解铜绿假单胞菌的耐药特点及指导临床抗菌药物选择。方法收集徐州市第一人民医院2013年临床分离出的335株铜绿假单胞菌进行药敏分析,并用WHONET5.6软件对实验结果和数据进行分析。结果临床分离出的335株铜绿假单胞菌对15种抗菌药物存在不同程度的耐药,其中对哌拉西林/他唑巴坦、丁胺卡那霉素、妥布霉素、环丙沙星、左氧氟沙星、头孢他啶、头孢吡肟、庆大霉素对铜绿假单胞菌的敏感性较高;对氨苄西林/舒巴坦、头孢曲松、氨苄西林、头孢噻肟耐药率高达97%以上。同一患者多次检测出该菌的,哌拉西林/他唑巴坦、头孢他啶、头孢吡肟、亚胺培南、庆大霉素药敏结果存在较大的波动性,同时铜绿假单胞菌的耐药谱有一定的趋向性。结论加强铜绿假单胞菌连续性病原学和耐药性监测,以应对急性耐药的发生和医院感染扩散,同时指导临床治疗。

Analysis of drug susceptibility test results of Pseudomonas aeruginosa in Xuzhou area

Objective To understand the drug resistance characteristics of pseudomonas aeruginosa and to guide the selection of clinical antibacterial drugs .Methods The clinically isolated 335 strains of pseudomonas aeruginosa from the Xuzhou Municipal First People′s Hospital in 2013 were collected and performed the drug susceptibility test .The test results and data were analyzed by using the WHONET5 .6 software .Results Clinically isolated 335 strains of pseudomonas aeruginosa had different degrees of re‐sistance to 15 kinds of antibacterial drugs ,in which the sensitivities to piperacillin/tazobactam ,amikacin ,tobramycin ,ciprofloxacin , levofloxacin ,ceftazidine ,cefepime and gentamicin were higher ;the resistance rate to ampicillin/sulbactam ,ceftriaxone ,ampicillin and cefotaxime was up to above 97% .In the same patients with several times of this bacterial detection ,larger volatility existed in the susceptibility results of piperacillin/tazobactam ,ceftazidine ,cefepime ,imipenem and gentamicin .Meanwhile the drug resitance spectrum of Pseudomonas aeruginosa had a certain tendency .Conclusion Strengthening continuous etiology and drug resistance moni‐toring is in response to the occurrence of acute drug resistance and nosocomial infection spread ,meanwhile guides clinical treatment .