血清NT-proBNP水平与代谢综合征相关性研究

目的探讨血清N末端B型钠尿肽原(NT-proBNP)与代谢综合征(MS)的相关性。方法选取该院内分泌科门诊符合MS诊断标准的患者61例为MS组,同时选取同期该院门诊查体健康人群50例为健康对照组。采用电化学发光法测定血清NT-proBNP水平。结果 MS组血清NT-proBNP水平为(112.6±18.6)pg/mL,显著高于健康对照组的(80.3±5.7)pg/mL,差异有统计学意义(P0.05)。血清NT-proBNP与静脉空腹血糖水平(FPG)、腰臀比(WHR)、收缩压(SBP)和三酰甘油(TG)呈正相关(r分别为0.710、0.626、0.595、0.595,P0.05);血清NT-proBNP与高密度脂蛋白胆固醇(HDL-C)呈负相关(r=-0.745,P0.05)。结论血清NT-proBNP与MS密切相关,血清NT-proBNP水平可作为评估MS患者早期预防高危因素的标志物之一。

Study on correlation between serum NT-proBNP level and metabolic syndrome

Objective To explore the relationship between serum N‐terminal pro‐brain natriuretic peptide(NT‐proBNP)and met‐abolic syndrome(MS) .Methods Sixty cases of MS in the endocrinology outpatients department of our hospital were selected as the MS group and contemporaneous 50 individuals undergoing the physical examination were selected as the healthy control group .The serum NT‐proBNP level was measured by the electrochemical luminescence method .Results The serum NT‐proBNP level was (112 .6 ± 18 .6)pg/mL]in the MS group ,which was significantly higher than(80 .3 ± 5 .7)pg/mL] in the healthy control group , the difference was statistically significant (P<0 .05) .Serum NT‐proBNP level was positively correlated with venous fasting plasma glucose(FPG) ,waist to hip ratio(WHR) ,SBP and TG(r=0 .710 ,0 .626 ,0 .595 ,0 .595 ,P<0 .05);serum NT‐proBNP level was negatively correlated with high density lipoprotein cholesterol (HDL‐C ,r= -0 .739 ,P<0 .05) .Conclusion Serum NT‐proBNP is closely related to MS ,and serum NT‐proBNP level can be used as one of the markers to assess the early prevention of MS high risk factors .