顺阿曲库铵引起过敏反应的概述

背景围手术期过敏反应是全身麻醉期间严重的并发症之一，麻醉期间使用的药物均可能导致发生，其中以神经肌肉阻滞剂（neuromuscular blocking agent, NMBA）多见。目的收集国内外的相关文献，综合分析顺阿曲库铵引起过敏反应的原因、临床表现及诊断方法。内容顺阿曲库铵是和种临床上较常用的非除极NMBA，早期认为顺阿曲库铵可释放少量组胺，对循环影响较小，应用前景广泛。但在使用过程中有研究报道，顺式阿曲库铵可引起严重的过敏反应，并伴有血流动力学改变和支气管痉挛症状。趋向随着顺阿曲库铵使用率的升高。由其引起的过敏反应的发生率也随之上升，麻醉医师对此现象应加以关注和重视。

A summary of anaphylactic reactions after cisatracurium administration

Background The incidence of perioperative hypersensitivity reactions,which can be life threatening,is one of the serious complications during general anesthesia.Drugs administered during anesthesia induction,especially neuromuscular blocking agents (NMBA),have a choice to make it happen.Objective This article is a summary about clinical feature of anaphylactie reactions after cisatracurium administration,and a discussion of advantagements about various diagnosis methods,depending on the related domestic and international literatures.Content Cisatracurium is a widely used new non-depolarising NMBA.Early reports suggest that cisatracurium released histamine is negligible.However,several cases of anaphylactic reactions after cisatracurium administration with severe symptoms of cardiovascular collapse and bronchospasm have been reported.Trend The incidence of allergic reaction,which is caused by increasing utilization of cisatracurium,is rising day by day.This paper intends to cause the attention of anesthesiologist,about allergic reaction caused by cisatracurium.