帕利哌酮血药浓度与血清泌乳素的相关性研究

目的探讨帕利哌酮血药浓度与血清泌乳素的关系。方法分别测定49例精神分裂症患者(男性组25例,女性组24例)服用帕利哌酮缓释片后第0、1、2、4、6、8周末帕利哌酮血药浓度与血清泌乳素浓度,并进行统计分析。结果两组患者服用帕利哌酮前后血清泌乳素浓度比较,差异有统计学意义(P0.01),帕利哌酮血药浓度的升高可引起血清泌乳素浓度的升高。结论在应用帕利哌酮治疗精神分裂患者的同时,应对患者体内帕利哌酮血药浓度和血清泌乳素浓度进行监测,以提高用药安全性,减少不良反应的发生。

Study on correlation between plasma paliperidone concentration and serum prolactin level

Objective To investigate the correlation between plasma paliperidone concentration and serum prolactin level .Meth‐ods The plasma paliperidone concentration and serum prolactin level at the ends of 0 ,1 ,2 ,4 ,6 ,8 weeks after taking paliperidone were separately detected in 49 patients with schizophrene (25 males and 24 females) .Then the statistical analysis was performed .Results The serum prolactin level in the schizophrenic patients had statistically significant difference before and after taking paliperidone(P<0 .05) .The increase of plasma paliperidone concentration could cause the increase of serum prolactin level .Conclusion Inthe application of paliper‐idone for treating schizophrene ,plasma paliperidone concentration and serum prolactin level should be monitored for improving the medication safety and decreasing the adverse drug reactions .