焦亡信号通路炎症小体与中枢神经系统疾病研究进展

焦亡是一种新发现并证实与炎症相关的细胞死亡方式,其特征为依赖于半胱天冬氨酸蛋白酶-1(caspase-1)的细胞程序性死亡,并伴有促炎症因子的释放,主要为白细胞介素1β和IL-18.虽然焦亡与坏死和凋亡有相似之处,但它们是迥然不同的生物学过程.越来越多的研究发现,焦亡相关信号通路在中枢神经系统疾病中起重要作用,包括急性脑感染、神经变性疾病、急性无菌性脑损伤和慢性无菌性中枢神经系统炎症.

The progression of the studies on inflammasome in the signaling pathway of pyroptosis in the diseases of central nervous system

Pyroptosis is a newly defined programmed cell death that associates with inflammation.Pyroptosis depends on the cysteinyl aspartate specific proteinase-1 (caspase-1),accompanied by the release of proinflammatory cytokines,mainly interleukin-1 β (IL-1 β) and interleukin-18 (IL-18).Unlike necrosis and apoptosis,pyroptosis is a unique way of cell death.A growing number of studies have found that pyroptosis related signaling pathway plays an important role in the diseases of central nervous system,including acute brain infection,neurodegenerative disease,acute sterile brain injury and chronic sterile central nervous system inflammation.