血清胱抑素C联合β2-微球蛋白检测对妊娠期糖尿病早期肾损伤的临床价值研究

目的探讨血清胱抑素C(CysC)联合β2-微球蛋白(β2-MG)检测对诊断妊娠期糖尿病(GDM)早期肾损伤的临床价值。方法选取孕28~40周妊娠糖尿病患者85例(GDM组)和健康妊娠孕妇50例(对照组)为研究对象,将肾小球滤过率(GFR)正常者30例作为A组GFR≥90mL/(min·1.73m~2)],GFR轻度下降25例作为B组60mL/(min·1.73m~2)≤GFR90mL/(min·1.73m~2)],GRF中度下降30例作为C组30mL/(min·1.73m~2)≤GRF60mL/(min·1.73m~2)],分别检测各组CysC、β2-MG、血尿素氮(BUN)及肌酐(Cr)水平,并对结果进行统计分析。结果 GDM组CysC、β2-MG、BUN、Cr检测水平均高于对照组,差异有统计学意义(P0.05);C组CysC、β2-MG、Cr水平均高于A、B组,差异有统计学意义(P0.05),BUN水平高于A、B组,但差异无统计学意义(P0.05);C组CysC及β2-MG联合检测阳性率高于A、B组,差异有统计学意义(P0.05)。结论 GDM肾损伤时血清CysC及β2-MG水平显著升高,可作为GDM早期肾损伤的敏感标志物,两者联合检测对GDM早期肾病的诊断及监测具有重要临床意义。

Study on clinical significance of combined detection of serum cystatin C and beta 2 microdobulin in early kidney damage of gestational diabetes

Objective To research the clinical value of serum cystatin C (CysC)and beta 2 microdobulin(β2‐MG)for diagnosing early renal damage of gestatinal diabetes mellitus (GDM ) .Methods Eighty‐five GDM patients with 28 to 40 gestational weeks (GDM group)the and 50 healthy pregnant women(control group)were chosen as the research subjects .Thirty cases of normal glo‐merular filtration rate(GRF)were taken the group AGFR≥90 mL/(min?1 .73 m2 )] ,25 cases of GFR slight decrease as the group B60 mL/(min?1 .73 m2 )≤GFR<90 mL/(min?1 .73m2 )]and 30 cases of GFR moderate decrease as the group C 30 mL/(min?1 .73m2 )≤GRF<60 mL/(min?1 .73 m2 )] .Then CysC ,β2‐MG ,blood urea nitrogen(BUN)and creatinine(Cr)were determined in each group .The detection results were statistically analyzed .Results The levels of CysC ,β2‐MG ,BUN and Cr in the GDM group were higher than those in the control group ,and the differences were statistically significant (P<0 .05);the levels of CysC ,β2‐MG and Cr in the group C were higher than those in the group A and B ,and the differences were statistically significant (P<0 .05) ,and the BUN level was higher than that in the group A and B ,but there was no statistical difference(P>0 .05);the positive rates of Cy‐sC andβ2‐MG combined detection were higher than those in the group A and B (P<0 .05) .Conclusion The levels of serum CysC andβ2‐MG are significantly increased in renal damage of GDM ,which can serve as the sensitive indicators of early renal damage in GDM and their combined detection is of great clinical significance for the diagnosis and monitoring of the early renal damage in GDM .