PTEN基因对T细胞生物活性影响的研究进展

PTEN基因能够影响T淋巴细胞的一系列生物学功能,尤其在生长、发育、增殖、分化、活化以及细胞因子分泌等方面.PTEN作为抑癌基因已被大家熟知,可以直接拮抗PI3K信号.然而PTEN基因的改变常常导致T细胞应答的异常甚至自身免疫性疾病以及T细胞恶性肿瘤的发生.通过对T细胞特异性缺失PTEN的小鼠模型分析,可使PTEN参与调节不同阶段T细胞信号功能以及在T细胞恶性肿瘤的发生过程中发挥的作用更加清晰明了.因此,对PTEN在T细胞中的作用进行研究具有重要的意义.

Research progress on the impact of PTEN gene on T cell biology

PTEN has been implicated in a variety of T cell biology,especially in growth,proliferation,differentiation,cytokine production and survival et al.PTEN as tumor suppressor gene was known,and can directly oppose PI3K signaling.However,alteration of this gene always leads to T cells response deficiency and even autoimmunity and T cells malignancy.Through the use of mouse model whose T cells are PTEN specifically deleted,it becomes increasing clear that the absence of PTEN plays important roles in the occurrence and development of T cells malignancy and multi-faced function in different stages of T cells signaling.Thus,it is significant to study the function of PTEN in regulating the T cell biology.