PTEN基因对T细胞生物活性影响的研究进展 |
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引用本文: | 赵宇,任欢. PTEN基因对T细胞生物活性影响的研究进展[J]. 国际免疫学杂志, 2016, 0(3): 298-301. DOI: 10.3760/cma.j.issn.1673-4394.2016.03.022 |
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作者姓名: | 赵宇 任欢 |
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作者单位: | 150081,哈尔滨医科大学免疫教研室 |
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摘 要: | PTEN基因能够影响T淋巴细胞的一系列生物学功能,尤其在生长、发育、增殖、分化、活化以及细胞因子分泌等方面.PTEN作为抑癌基因已被大家熟知,可以直接拮抗PI3K信号.然而PTEN基因的改变常常导致T细胞应答的异常甚至自身免疫性疾病以及T细胞恶性肿瘤的发生.通过对T细胞特异性缺失PTEN的小鼠模型分析,可使PTEN参与调节不同阶段T细胞信号功能以及在T细胞恶性肿瘤的发生过程中发挥的作用更加清晰明了.因此,对PTEN在T细胞中的作用进行研究具有重要的意义.
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关 键 词: | PTEN T细胞 PI3K信号通路 |
Research progress on the impact of PTEN gene on T cell biology |
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Abstract: | PTEN has been implicated in a variety of T cell biology,especially in growth,proliferation,differentiation,cytokine production and survival et al.PTEN as tumor suppressor gene was known,and can directly oppose PI3K signaling.However,alteration of this gene always leads to T cells response deficiency and even autoimmunity and T cells malignancy.Through the use of mouse model whose T cells are PTEN specifically deleted,it becomes increasing clear that the absence of PTEN plays important roles in the occurrence and development of T cells malignancy and multi-faced function in different stages of T cells signaling.Thus,it is significant to study the function of PTEN in regulating the T cell biology. |
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Keywords: | PTEN T cells PI3K signaling pathway |
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