髓过氧化物酶检测对急性缺血性脑卒中的临床意义

目的 探讨急性缺血性脑卒中患者血清髓过氧化物酶(MPO)水平,分析其与颈动脉粥样硬化斑块类型、神经功能缺损程度及日常生活活动能力(巴塞尔指数)的相关性。方法 选取78例急性缺血性脑卒中患者,按巴塞尔指数分为好、中、差3个组;根据神经功能缺损程度评分(中国人卒中量表)标准分为轻度损伤组(0~15分)、中度损伤组(16~30分)、重度损伤组(31~45分);根据动脉粥样硬化斑块类型分为软斑组、混合斑组、硬斑组。比较不同组别患者血清MPO水平结果。结果 神经功能缺损程度越严重,患者血清中MPO水平越高,且各组间比较,差异有统计学意义(P0.05);巴塞尔指数越好,患者血清MPO水平越低;软斑组、混合斑组、硬斑组之间血清MPO水平不同,血清MPO水平差异有统计学意义(P0.05),且动脉粥样硬化斑块类型与神经功能缺损和巴塞尔指数级别具有相关性。结论 急性缺血性脑卒中的发生与血清MPO水平、神经功能缺损程度、巴塞尔指数,以及动脉粥样斑块稳定性相关,血清MPO水平有助于判断病情,并指导临床诊断与治疗。

The clinical significance of serum MPO in patients with acute ischemic cerebral stroke

Objective To study the changes of serum myeloperoxidase(MPO)in patients with acute ischemic stroke ,and to probe into the relationship of serum MPO with types of carotid atherosclerotic plaques ,the degree of neural function defect and the activi‐ties of daily living (Barthel Index) .Methods Totally 78 cases of patients with acute ischemic stroke was selected as observation ob‐jects .The patients with acute ischemic stroke were divided into good ,medium and poor three groups according to Barthel index . Based on the scoring of neurologic impairment degree from standards of CSS :mild impairment group(0 to 15 points) ,moderate im‐pairment group(16 to 30 points) ,and severe impairment group(31 to 45 points) .Based on the type of atherosclerotic plaques all pa‐tients were divided into soft plaque group ,mixed plaque and hard plaque group .The 1evels of serum MPO was compared between different group .Results The heavier nerve function defect degree ,the levels of serum MPO in patients with ischemic stroke were higher ,and it had significant difference between groups (P<0 .05) .The Barthel index was the better ,the levels of serum MPO was lower .The levels of serum MPO was different among the soft plaque group ,mixed plaque and hard plaque group ,and its were sig‐nificantly different between the three groups ,and the type of atherosclerotic plaque was related to the neural function defect and Barthel index level .Conclusion Ischemic stroke is associated with serum MPO levels ,neurological deficits ,Barthel index and stabil‐ity of atherosclerotic plaque ,and the levels of serum M PO is helpful for judging state of the disease and guiding in clinical diagnosis and treatment .