| 细胞自噬的调控与自噬程序性死亡的研究进展 |
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| 引用本文： | 韦勇,杨四军.细胞自噬的调控与自噬程序性死亡的研究进展[J].国际免疫学杂志,2016(5):493-497. |
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| 作者姓名： | 韦勇 杨四军 |
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| 作者单位： | 1. 430072,武汉大学生命科学学院;2. 病毒学国家重点实验室, 武汉大学动物实验中心/ABsL-Ⅲ实验室,430071 |
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| 基金项目： | 武汉大学优秀青年学术骨干启动基金，湖北省自然科学基金重点项目(2015CFA075)the outstanding young academic backbone of start-up funding of Wuhan University，the key project of Natural Science Fund of Hubei province(2015CFA075) |
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| 摘 要： | 自噬(autophagy)是一种溶酶体依赖性降解途径,涉及细胞内长寿蛋白和受损伤细胞器的降解,其既是细胞保守的自我防御机制,又是一种程序性细胞死亡机制(PCD),与机体的多种疾病有密切关系.自噬具有独特的形态改变和特有的调控通路,自噬的调控涉及到多种机制、如翻译后修饰等.凋亡是研究最清楚的程序性细胞死亡机制,凋亡与细胞自噬程序性死亡之间存在着复杂的关系.对哺乳动物细胞自噬的分子调控机制,自噬程序性细胞死亡过程及其与凋亡的关系等方面进行探讨很有意义.
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| 关 键 词： | 自噬 自噬分子机制 细胞自噬性死亡 |
The regulation of autophagy and autophagic programmed cell death |
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| Abstract: | Autophagy is a lysosomal-dependent degradation pathway and involved in the degradation of long-lived protein and damaged organelles in cells.It is not only a conservative self-defense mechanism for cells,but also a mechanism of programmed cell death (PCD).Autophagy is closely related to a variety of diseases.It has a unique morphology change and specific regulatory pathway.Autophagy regulation involves a variety of mechanisms,such as post-translational modification.Apoptosis is a well-understoed mechanism of programmed cell death.There is a complicated relationship between apoptosis and autophagy.It is important to discuss the molecular mechanism of autophagy of mammalian cells,and its relationship with apoptosis. |
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| Keywords: | Autophagy The mechanism of autophagy Autophagic programmed cell death |
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