| 免疫细胞在心肌重塑中的作用 |
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| 引用本文： | 韩科强,门素珍,刘巍.免疫细胞在心肌重塑中的作用[J].国际免疫学杂志,2016(3):254-257. |
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| 作者姓名： | 韩科强 门素珍 刘巍 |
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| 作者单位： | 150001,哈尔滨医科大学附属第一医院内科危重症科 |
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| 基金项目： | 国家自然科学基金(81270310)，黑龙江省教育厅海外学人重点项目(1252HQ013)，黑龙江省留学归国基金(LC2011C07)，The National Natural Science Fund of China(81270310)，The Education Department of Heilongjiang Province Overseas Students of Key Projects(1252HQ013)，Heilongjiang Province Returned Funds(LC2011C07) |
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| 摘 要： | 心肌重塑几乎与所有类型的心脏疾病的发生发展相关,是一个重要的全球性健康问题.这种病理性重塑过程包括心室扩张、心肌炎症反应和心肌细胞肥大,最终导致心力衰竭的发生.在各种类型的心肌损伤后,心脏从纤维细胞转化为肌成纤维细胞,随后并沉积在细胞外基质中,这是心肌纤维化的重要病理机制.同时免疫细胞的激活及其介导的炎症反应也参与了心肌重塑的发生与发展,因而了解免疫细胞导致心肌重塑的可能病理机制可为临床防治和逆转心肌重塑提供新的靶点.
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| 关 键 词： | 免疫细胞 炎症反应 心肌重塑 |
Effects of immunological cells in cardiac remodeling |
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| Abstract: | Myocardial remodeling is an important world-wide health problem associated with nearly all kinds of heart diseases.This remodeling process involves pathological changes that include chamber dilation,myocardial inflammation and cardiomyocyte hypertrophy,which ultimately leads to heart failure.The differentiation of cardiac fibroblasts into myofibroblasts and the subsequent deposition of the extracellular matrix are associated with myocardial fibrosis following various types of myocardial injury.The activation of immune cells and the inflammatory response are involved in the occurrence and development of cardiac remodeling.This reriew paper presents the possible pathological mechanisms of immune cells in leading to ventricular remodeling.The related studies may provide new targets for the clinical prevention and reversal of myocardial remodeling. |
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| Keywords: | Immune cells Inflammatory reaction Myocardial remodeling |
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