Epstein-Barr virus-related Hodgkin's disease showing B cell lineage in an immunosuppressive patient seropositive for HTLV-I |
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| Authors: | Tetsuya Murata Shigeo Nakamura Hiroya Kato Yasushi Yatabe Taizo Shiraishi Makoto Kuroda Ryulchi Yatani Taizan Suchi |
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| Affiliation: | Department of Pathology and Clinical Laboratories, JA Suzuka Hospital, Suzuka;Department of Pathology and Clinical Laboratories, Aichi Cancer Center Hospital, Nagoya;Department of Pathology, Mie University School of Medicine, Tsu;Department of Pathology, Fujita Health University, Aichi, Japan |
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| Abstract: | A case of Hodgkln's disease (HD), lymphocyte depression (LD) type In an Immunosuppressive patient is described. The patient was a 48-year-old male and his parents were born In the Kyushu area, which is an endemic area for adult T cell lymphomaheukemla (ATL). He was seropositive for ATL virus (ATLV, also referred to as HTLV-I) and showed a marked Immunosuppressive condition. He developed LD-HD and Pneumocystis carinii pneumonia, and died due to respiratory failure. The Immunohistochemical and in situ hybridization analyses revealed that the Reed-Sternberglike cells In the lymph node biopsy sample were positive for Ber-H2 (CD30), Leu-M1 (CD15), L-26 (CD20), Bcl-2, p53 and EBER, the viral genome of Epstein-Barr virus (EBV). |
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| Keywords: | Epstein-Barr virus Hodgkin's disease immunosuppression |
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