卵巢肿瘤组织中HABP-1、VEGF的表达及其临床病理意义

目的 研究HABP-1、VEGF在卵巢肿瘤组织中的表达及其临床意义。方法 通过应用免疫组化SP法来检测20例卵巢良性肿瘤、30例卵巢交界性肿瘤、102例卵巢恶性肿瘤中HABP-1和VEGF的表达情况。结果 HABP-1和VEGF在卵巢癌和卵巢交界性肿瘤中的阳性表达率显著高于卵巢良性肿瘤。HABP-1在卵巢癌组织中的阳性表达率与患者的年龄和病理类型无统计学意义(P＞0.05),而与病理分级、临床分期、淋巴结和腹膜转移等有显著统计学意义(P＜0.05)。结论 HABP-1和VEGF在卵巢癌的发生、发展中起到了至关重要的作用,可作为判断卵巢癌恶性程度、病情进展的重要指标,联合检测用于指导临床诊断。

Expression and clinical significance of HABP-1 and VEGF in ovarian carcinoma

Objective To study the expression and clinical significance of HABP - 1 and VEGF in ovar- ian carcinoma. Methods 20 cases with benign ovarian tumor,30 cases with border ovarian tumor and 102 cases with malignant ovarian tumor were used to measure the positive expression rate of HABP - 1 and VEGF by immunohistochemical SP method. Results The positive expression rate of HABP - 1 and VEGF was significantly higher in malignant and borderline groups than that in benign group（ P 〈0.0l ）. The positive expression rate of HABP - 1 did not have association with age or histological type （ P 〉 0.05 ） , but with the FIGO stage and metastasis （ P 〈 0. 05 ）. Conclusion The expression of HABP - 1 had positive correlation with the expression of VEGF. Both of them are extremly useful and meaningful during the carcinogenesis, development and transformation. The ex- pressions of HABP - 1 and VEGF play an important role in diagnosis of epithelial ovarian cancer.