紫杉醇周疗同步放疗治疗复发转移乳腺癌

目的 探讨伴有压迫症状的脑转移或骨转移且合并内脏转移的晚期乳腺癌合理的治疗模式。方法 化疗方案均为单药紫杉醇80 mg/m² d1,d8、d15,21天为1周期。全脑放疗采用高能X线全脑对穿照射,总量分别为45 Gy和40 Gy。骨放疗采用X线外照射,总量分别为33 Gy和40 Gy。放化疗同步进行。临床疗效评定按WHO实体瘤疗效评定标准。每完成2个周期化疗进行一次疗效评价。结果 4例患者总体疗效评价均为PR,神经系统压迫症状及骨痛症状均得到缓解,TTP分别为9个月、5个月、6⁺个月和8.5个月。结论 采用同步放化疗治疗有压迫症状的脑转移或骨转移且合并内脏转移的晚期乳腺癌,可以有效缓解症状、改善生存质量。

Concurrent chemoradiotherapy with weekly Paclitaxol in advanced breast cancer

Objective. To investigate the treatment pattern in patients with visceral organ metastatic breast cancer who having symotoms of brain or bone metastasis involved. Method The total dose of whole - brain radiotherapy were 45 Gy and 40 Gy, respectively. Ther bone radiotherapy were 33 Gy and 40 Gy, respectively. At the same timelehemolherapy were given with Paclitaxol 80 mg/m2,dl ,8,15, every 21 days as one cycle. The efficacy was evaluated every 2 cycles of chemotherapy according to WHO standard. Result The objective efficacy of 4 patifts were PR, The constricts symptoms of the CNS and pain of the bone were relieved. TTP of 4 patients were 9,5,6 ＋ and 8.5 months, respectively. Conclusion Treatment pattern of concurrent chemoradiotherapy in visceral organ metastatic patients with having symptoms of brain or bone metastasis result in a effectiveness to reduce symptoms and improve QOL.