AEG-1与Ki-67在上皮性卵巢组织中的表达及其临床病理相关性的研究

目的 探讨AEG-1和Ki-67在上皮性卵巢组织中的表达与临床病理因素的关系,同时为研究卵巢癌的发病机制提供一定的理论基础。方法 通过免疫组化的方法检测在21例正常卵巢组织,32例卵巢交界性肿瘤,157例性恶性肿瘤中AEG-1和Ki-67的蛋白表达水平,并运用统计学方法分析AEG-1与Ki-67之间的相关性,同时观察其表达与上皮性卵巢肿瘤的临床病理因素之间的相关性。结果 AEG-1和Ki-67在正常卵巢组织中均未见表达,在癌组织中的表达水平显著高于交界性肿瘤中的表达水平,并且发现两者之间的表达存在显著的相关性。AEG-1的高表达水平与上皮性卵巢癌患者组织学分化程度,残留肿物大小及临床分期之间有显著统计学意义(P＜0.01),但与患者年龄,血清CA125值,腹水量及病理学类型之间均无统计学意义(P＞0.05)。结论 AEG-1和Ki-67可能在上皮性卵巢癌的发生与发展中扮演重要的作用。同时其高表达水平可能作为判断卵巢癌恶性程度、病情进展的重要指标,联合检测其表达情况有助于卵巢癌患者的早期发现与治疗。

AEG-1/Ki-67 expressions in various ovarian tissues and clinical significance of AEG-1 in epithelial ovarian carcinoma

Objective To investigate AEG - 1 （ Astrocyte Elerated Gene - 1 ） and Ki - 67 expression in different ovarian tissues and the relationship between them;to assess the clinical significance of AEG - 1 expres- sion in epithelial ovarian carcinoma（EOC）. Methods Immunohistochemical staining was employed to detect the expressions of AEG - 1 and Ki -67 in different ovarian tissues from 21 cases of normal tissues ,32 cases of borderline tissues and 157 malignant tissues. The relationship between AEG - 1 expression and clinicopathological factors was also assessed in these patients. Results We demonstrated that AEG - 1 expression levels were gradually elevated in normal tissues, borderline tissues and EOC tissues, respectively. Moreover, there was a similar trend for Ki -67 expression （as a proliferative index）from normal tissues, borderline tissues to EOC tissues. Statistical analysis revealed that AEG - 1 expression was markedly correlated with residue tumor size （ P = 0. 0007 ）, the FIGO stage（ P = 0. 0063 ）, Ki - 67 expression （ P 〈 0.01 ） and histological differentiation （ P 〈 0. 001 ） in the ovarian cancer patients. Conclusion AEG - 1 overexpression in EOC may be associated with tumor progression, sugges- ting AEG - 1 as a potential preventive target in these patients.