| 非ST段抬高急性冠脉综合征患者高敏C反应蛋白与抵抗素、脂联素的关系及临床意义 |
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| 引用本文： | 李潞,赵红丽,张晓丹,王帅,李纯,谭力力,周杨. 非ST段抬高急性冠脉综合征患者高敏C反应蛋白与抵抗素、脂联素的关系及临床意义[J]. 实用医学杂志, 2011, 27(17): 3132-3134. DOI: 10.3969/j.issn.1006-5725.2011.17.016 |
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| 作者姓名： | 李潞 赵红丽 张晓丹 王帅 李纯 谭力力 周杨 |
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| 作者单位： | 沈阳医学院沈洲医院心内科,110002 |
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| 基金项目： | 辽宁省科学技术计划项目 |
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| 摘 要： | 目的:探讨非ST段抬高急性冠脉综合征(ACS)患者高敏C反应蛋白(hs-CRP)与抵抗素、脂联素(Adp)的关系及临床意义。方法:选取非ST段抬高ACS的患者106例,分为不稳定性心绞痛(UA)组69例及急性非ST段抬高心肌梗死(NSTEMI)组37例;另入选稳定型心绞痛(SAP)组35例及健康对照组35例。所有入选患者行总胆固醇(TC)、低密度胆固醇(LDL)、高密度胆固醇(HDL)、甘油三酯(TG)及hs-CRP检测,并测定Adp及抵抗素水平。结果:与SAP组比较,UA组及NSTEMI组抵抗素水平增高,Adp减低(P<0.05)。NSTEMI组hs-CRP水平较健康对照组及SAP组明显增高(P<0.05)。非ST段抬高ACS患者中,高危险组hs-CRP及抵抗素水平增高,Adp减低(P<0.05);相关性分析显示,Adp与抵抗素呈负相关(r=-0.829,P<0.001),抵抗素与HDL呈负相关(r=-0.312,P=0.047),Adp与HDL呈正相关(r=0.304,P=0.053)。结论:高危非ST段抬高ACS患者hs-CRP、抵抗素水平明显高于低危险组,而Adp水平显著低于中低危险组;hs-CRP、抵抗素、Adp水平与冠状动脉斑块稳定性有关。
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| 关 键 词： | 冠状动脉疾病 C反应蛋白 脂联素 抵抗素 |
Association between high-sensitivity C-reactive protein and adiponectin, resistin in patients with non-ST elevated acute coronary syndrome |
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| LILu,ZHAO Hong-li,ZHANG Xiao-dan,WANG Shuai,LI Chun,TAN Li-li,ZHOU Yang. Association between high-sensitivity C-reactive protein and adiponectin, resistin in patients with non-ST elevated acute coronary syndrome[J]. The Journal of Practical Medicine, 2011, 27(17): 3132-3134. DOI: 10.3969/j.issn.1006-5725.2011.17.016 |
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| Authors: | LILu ZHAO Hong-li ZHANG Xiao-dan WANG Shuai LI Chun TAN Li-li ZHOU Yang |
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| Affiliation: | LI Lu,ZHAO Hong-li,ZHANG Xiao-dan,WANG Shuai,LI Chun,TAN Li-li,ZHOU Yang. Department of Cardiology,the Shenzhou Hospital Affiliated to Shenyang Medical College,Shenyang 110002 |
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| Abstract: | Objective To investigate the association between high-sensitivity C-reactive protein (hs-CRP) and adiponectin, resistin in patients with non-ST elevated acute coronary syndrome (ACS). Methods One hundred and six patients with non-ST elevated ACS were divided into two groups: unstable angina group (UA group, n = 69) and non-ST elevated myocardial infarction group (NSTEMI group, n = 37). Another 35 patients with stable angina pectoris (SAP group) and 35 healthy controls (control group) were also included in t... |
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| Keywords: | Coronary artery disease C-reactive protein Adiponectin Resistin |
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