IMRT在老年宫颈癌治疗中的应用价值

目的 探讨IMRT在老年宫颈癌初治患者治疗中的临床应用价值。方法 选择2008年1月—2009年1月在我院收治的老年宫颈癌患者60例,其中常规放疗(CRT)组30例,IMRT组30例,比较两组患者的疗效和放疗并发症。结果IMRT组和CRT组近期有效率分别为86.7%和90.0%,差异无统计学意义(P＞0.05);IMRT组1、2年生存率分别为86.7%、73.3%,CRT组1、2年生存率分别为80.0%、63.3%,差异无统计学意义(P＞0.05);IMRT组较CRT组小肠、直肠、膀胱的受照射剂量和体积均明显减少(P＜0.05);近期胃肠道及泌尿系放疗反应IMRT组发生率明显低于CRT组(P＜0.05);远期放射性直肠炎、膀胱炎发生率明显低于CRT组,差异有统计学意义(P＜0.05)。结论 IMRT技术与常规放疗方法相比对老年宫颈癌初治患者是一种更为有效的治疗手段,临床近期疗效满意,放疗并发症明显降低。

Intensity modulated radiation therapy for gerontal cervical cancer patients

Objective To discuss the clinical significance of intensity modulated radiation therapy（ IM- RT） in gerontal cervical cancer. Methods Sixty patients of gerontal cervical cancer in our study. Thirty patients were treated by IMRT, and thirty were treated by CRT. We compared short - term efficacy and complications between two groups. Results The tumour regression rates were 86.7% for IMRT group and 90.0% for CRT group （ P 〉 0.05 ） respectively. The 1 - year and 2 - year survival rates were 86.7% and 73.3% in IMRT group respectively,which were no significant difference compared with those in CRT group（80.0% and 63.3% ）, （P 〉 0.05）. Compared with CRT group, the doses and volume of small intestine, rectum, bladder in IMRT group were significantly decreased（ P 〈 0.05 ）. The incidence rates of acute gastrointestinal tract and urinary system radiation reaction in IMRT group were significantly lower than those in the CRT group（P 〈 0.05 ）. The incidences of long -term radiation proctitis, cyctitis in IMRT group were significantly lower than those in the CRT group （P 〈 0. 05）. Conclusion Compared with CRT in gerontal cervical cancer, IMRT did not improve local tumor control rate and the recent survival rate, but significantly reduced the response to acute and chronic radiation.