静脉用免疫球蛋白在系统性红斑狼疮治疗中的应用

静脉用免疫球蛋白(IVIg)主要通过Fc受体介导免疫调节作用治疗系统性红斑狼疮(SLE),其他机制包括抑制补体介导的损伤,调控细胞因子的产生;调控独特型抗体网络,中和病理性自身抗体;调节B细胞和T细胞功能,下调抗体的产生等。IVIg已成功治疗SLE相关的顽固性血小板减少症、中枢神经系统狼疮、狼疮性肾炎及对传统免疫治疗无效或同时合并感染的SLE。

Intravenous immunoglobulin therapy and systemic lupus erythematosus

Intravenous immunoglobulin(IVIg) therapy immunomodulates systemic lupus erythematosus by interacting with various Fc receptors.Additional mechanisms include inhibition of complement-mediated damage,modulation of cytokine production,and T-and B-lymphocyte function,downregulation of autoantibody production,manipulation of the idiotypic network,and neutralization of pathogenic autoantibodies.Intravenous immunoglobulin has been used successfully to treat SLE patients with a broad spectrum of clinical manifestations,such as refractory thrombocytopenia,central nervous system(CNS) involvement,lupus nephritis,and in those patients who are resistant to conventional treatment,or in patients who have concomitant infections.