中国食管癌患者p53基因改变与吸烟、饮酒的Meta分析

目的 探讨吸烟、饮酒与中国人群食管癌p53基因改变的关系。方法 在Medline和CNKI数据库中系统检索相关文献,应用Meta分析的方法进行定量综合分析。结果 共纳入14篇文献,累积食管癌2 108例,p53基因改变1 142例,平均阳性率为54.2%。在中国人群中,吸烟与食管癌p53基因改变的合并OR值为1.61(95% CI:1.09-2.38),P=0.003;饮酒与食管癌p53基因改变的合并OR值为1.91(95% CI:1.44-2.53),P＜0.001。结论 中国人群中,吸烟、饮酒均与食管癌p53基因改变有显著联系。

The meta-analysis between p53 alteration and smoking, alcohol consumption in esophageal cancer among Chinese population

Objective To explore the association between smoking,alcohol consumption and p53 alteration in esophageal cancer among Chinese population. Method A systematic search was performed using the Medline and CNKI databases, and the eligible literatures were systematic reviewed. Results Fourteen studies were eligible for analysis, involving 2108 esophageal cancer cases and 1142 （54.2%）p53 alteration cases. Among Chinese population, the pooled OR for the association between smoking, alcohol drinking and p53 alteration in esophageal cancer were 1.61 （ 95 % CI ： 1.09 - 2.38 ; P = 0.003 ） and 1.91 （ 95 % CI ： 1.44 - 2.53 ; P 〈 0.001 ）, respectively. Conclusion The findings of this meta - analysis indicated that there were significant associations between smoking, alcohol consumption and p53 alteration in esophageal cancer among Chinese population.