血管内皮细胞生长因子促进激素性股骨头坏死修复

[目的]探讨应用血管内皮细胞生长因子治疗激素性股骨头坏死的方法。[方法]新西兰兔30只，22只兔耳缘静脉注射马血清，臀肌注射醋酸泼尼松龙，制造激素性股骨头坏死动物模型。动物随机分为3组：A组：VEGF治疗组，B组：对照组，C组：正常对照组。治疗组骨穿刺针行经皮注射血管内皮细胞生长因子脂质体至股骨头。于治疗后5周，采用影像学方法观察股骨头结构变化，病理组织学观察股骨头骨组织、骨髓造血组织及血管的变化。[结果]VEGF治疗组，X线及CT检查显示：模型股骨头结构变清晰，骨质破坏明显修复；HE染色结果：VEGF治疗组可见软骨细胞修复性增生，骨髓腔造血组织出现增生，栓塞的血管旁边出现新生的血管。[结论]VEGF治疗股骨头坏死能促进新血管生成及骨修复。

Effect on avascular necrosis of the femoral head with vascular endothelial growth factor

[Objective]To explore a new method for the therapy of avaseular necrosis of the femoral head with vascular endothelial growth factor(VEGF).[Method]Thirty New Zealand white rabbits were chosen as experimental animals and avascularnecrosis of the femoral head model of 22 rabbits were established.Animals were egually divided into three groups:VEGF group,natural repair group,normal group.The medicament was injected to the femoral head by percutaneous injection in group A and normal saline in group B.The repairing process of bone necrosis of femoral head were studied.[Result]Compared to the untreated model group(group C),the femoral head of VEGF groups showed significant new vessel formation,number of empty bone lacunae decreased and hematopoietic tissue improving in marrow cavity.X-ray film and CT revealed evident that veGF could enhance repairing of the femoral head.[Conclusion]Pereutaneous injection of VEGF to the necro femoral head could significantly enhance bone tissue angiogenesis and ameliorated repair of osteonecrosis,thus providing a potential method for the treatment of the femoral head necrosis.