抗生素骨水泥结合膜诱导技术治疗胫骨骨髓炎的临床研究

目的观察研究使用抗生素骨水泥抗感染并形成诱导膜,采用膜诱导自体骨或结合异体骨材料移植技术治疗胫骨骨髓炎及其术后骨缺损的临床效果。方法自2010年9月~2015年9月手术治疗15例胫骨骨髓炎患者,一期病变切除,抗生素骨水泥植入,外固定支架固定,6~8周诱导膜形成后二期手术取出骨水泥,自体骨或结合异体骨材料移植,采用膜诱导技术修复骨缺损促进骨质愈合。结果随访12~52月,15例患者感染无复发,骨折均获愈合,功能恢复良好。结论采用抗生素骨水泥膜诱导自体骨或结合异体骨材料移植技术治疗胫骨骨髓炎及其术后骨缺损可以取得良好的治疗效果。

The clinical study of bone cement containing antibiotics and induced membrane technique to treat tibia osteomyelitis

Objective To investigate the clinical efficacy of induced membrane technique with bone cement containing antibiotics and bone grafting technique with autologous and allogeneic bone to treat chronic osteomyelitis and bone defects in tibia after fracture operation. Methods From Sep 2010 to Sep2015, a total of 15 patients with tibia osteomyelitis were treated with Excision of necrotic and infected tissues and external fixator technique andbone cement containing antibiotics grafting in first stage.Within 6 to 8 weeks the induced membrane was formed.The autologous and allogeneic bone were grafted and the induced membrane technique was applied to promote new bone forming in second stage.Rresults 15 cases had no reinfection and achieved complete bone healing after 12 to 52 months follow-up. All the patients had satisfactory function. Conclusion The induced membrane technique with bone cement containing antibiotics and bone grafting technique with autologous and allogeneic bone to treat chronic osteomyelitis and bone defects in tibia after fracture operation can provide satisfactory results.