基于共享系统开展新疆地区HIV 感染者中医证候分布特征的相关性研究

目的：基于临床科研信息共享系统，以新疆地区HIV感染者为研究对象，对其中医证候分布特征进行数据挖掘分析。方法：利用我院临床科研信息共享系统构建数据库（数据来自2011年5月-2012年3月间1151份格式化电子病历），通过Oracle、ETL软件进行数据处理，采用数据可视化分析进行数据挖掘。结果：新疆地区HIV感染者证候分布相对集中的气虚湿阻、气阴两虚、肝肾阴虚、肝郁气滞四大类。气虚湿阻证候年龄相对集中在20-30岁范围内，女性居多，性传播感染者比重较大。气阴两虚证候年龄相对集中在30-40岁范围内，男性居多，静脉吸毒感染者比重较大。各证候中维吾尔族人群比例均占较大比重。病程与证候的变化关系按1年、3年、5年分层分析体现了实证、虚实夹杂证、虚证由实至虚的传遍转化规律。结论：利用临床科研信息共享系统可用于临床大数据的处理，挖掘的结果可用于指导临床实践，为中医临床科研提供很好的平台。

Correlational Study on Traditional Chinese Medicine Syndrome Distribution Characteristics of HIV Infection in Xinjiang Region Based on Information Sharing System

This paper was aimed to study traditional Chinese medicine (TCM) syndrome distribution characteristics of HIV infection in Xinjiang region based on the Clinical Medical Research Information Sharing System (CMRISS).CMRISS was used to establish a database (data were from 1151 hospital electronic medical records from May 2011 to March 2012). Oracle and ETL software were used in the data processing. Visualization analysis was used in the datamining. The results showed that syndrome distribution of HIV infection in Xinjiang region was concentrated in four categories with the blockade of dampness due to qi deficiency, deficiency of both qi and yin, yin deficiency of liver and kidney, and the stagnation of liver qi. The syndrome of blockade of dampness due to qi deficiency was relatively concentrated in the range of 20-30 years old, with the majority of female population. The proportion of sexually transmitted infection was more. The syndrome of deficiency of both qi and yin was relatively concentrated in the age range of 30-40 years old, with the majority of male population. The large proportion of infection was due to intravenous drug use. Among different TCM syndromes, Uyghur population occupied relatively large part. Stratified analysis on disease course due to the change of TCM syndrome according to 1 year, 3 years and 5 years revealed the disease development rule from excess syndrome, deficiency combined with excess, to deficiency syndrome. It was concluded that the application of CMRISS was able to process a large amount of clinical data. The data mining results can be used to guide clinical practice. It provided a better platform for the scientific research of TCM clinical practice.