他汀序贯疗法对急性冠状动脉综合征合并2型糖尿病患者炎性因子和脂联素影响的研究

目的探讨他汀序贯疗法对急性冠状动脉综合征(ACS)合并2型糖尿病患者炎性因子和脂联素的影响。方法选择ACS患者119例,将合并糖尿病患者61例分为对照1组32例和序贯治疗1组29例,ACS未合并糖尿病患者58例分为对照2组28例和序贯治疗2组30例;另选糖尿病患者31例为糖尿病对照组,正常体检者26例为正常对照组。比较各组脂联素、可溶性血管细胞黏附因子1(sVCAM-1)、脂蛋白磷脂酶A2(Lp-PLA2)、妊娠相关蛋白A(PAPP-A)水平。结果与正常对照组比较,糖尿病对照组脂联素明显降低,sVCAM-1、Lp-PLA2、PAPP-A明显升高(P<0.01)。与对照1组和对照2组比较,序贯治疗1组和序贯治疗2组脂联素水平明显升高,sVCAM-1、Lp-PLA2、PAPP-A明显降低(P<0.01)。结论他汀序贯疗法可明显提高合并或未合并糖尿病ACS患者的脂联素水平,降低其炎症标记物水平。ACS合并或未合并糖尿病患者应用他汀序贯疗法后,对脂联素和血清炎症标记物的影响无明显差异。

Effect of statin sequential therapy on adiponectin and inflammatory markers in acute coronary syndrome patients with type 2 DM

Objective To study the effect of statin sequential therapy on adiponectin and inflammatory markers in acute coronary syndrome(ACS) patients with DM.Methods Of the 119 ACS patients included in this study,61 with DM were divided into control group 1(n=32) and sequential therapy group 1(n=29),58 without DM were divided into control group 2(n=28) and sequential therapy group 2(n=30).Another 31 DM patients served as a DM control group and 26 subjects undergoing health check served as a normal control group.Their serum levels of adiponectin,soluble vascular adhesion molecular 1(sVCAM-1),lipoprotein-associated phospholipase A2(Lp-PLA2),pregnancy-associated plasma protein A(PAPP-A) were measured and compared.Results The serum adiponectin level was significantly lower while the serum sVCAM-1,Lp-PLA2 and PAPP-A levels were significantly higher in DM control group than in normal control group(P<0.01).The serum adiponectin level was significantly higher while the serum sVCAM-1,Lp-PLA2 and PAPP-A levels were significantly lower in sequential therapy groups 1 and 2 than in control groups 1 and 2(P<0.01).Conclusion Statin sequential therapy can significantly increase the adiponectin level and decrease the inflammatory markers levels in ACS patients with or without DM.No significance difference is found in adiponectin and inflammatory markers levels in ACS patients with or without DM after statin sequential therapy.