纳米氧化镁对小鼠血清生化指标的影响

目的探讨纳米镁材料对小鼠血清生化指标的影响。方法按照固定剂量(5g/kg)法以镁粉、微米氧化镁和纳米氧化镁一次经口灌胃。14d后处死动物取血清观察常规生化指标的变化。结果纳米氧化镁组小鼠血清LDH和ALP明显低于微米氧化镁组(P<0.05),但与对照组相比无明显变化(P>0.05)。结论纳米氧化镁对血清LDH和ALP的影响与微米氧化镁材料有明显差别,其生化毒性作用可能与微米氧化镁材料有所不同。

Effect of nano-particle magnesia on some serum biochemical indices in mice

Objective To explore the effect of nano-particle magnesia(magnesium oxide)on mouse serum biochemical indices.Method Mice were treated by a single oral dose of nano-and micro-particle magnesia and magnesium powder at dose of 5 g/kg body weight by gastric tube.The mice were sacrificed 14 days after treatment and blood specimens were collected from them and serum was tested for changes in biochemical analysis.Result Serum activities of LDH and ALP were significantly lower in mice treated with nano-particle magnesia than in those with micro-particle magnesia(P<0.05),but there was no significant difference between mice with nano-particle magnesia and controls(P>0.05).Conclusion Nano-particle magnesia may have different biochemical toxicity on mice,as compared with micro-particle magnesia.