血清C反应蛋白与前白蛋白的测定在新生儿感染性疾病中的应用价值

目的探讨新生儿细菌感染时血清C反应蛋白（CRP）和前白蛋白（PA）的变化对疾病诊断、病情评估及疗效观察的临床意义。方法用免疫比浊法检测59例正常足月新生儿（正常对照组）和78例新生儿（细菌感染组）细菌感染治疗前、治疗后第2天、第7天血清CRP和PA水平。结果与正常对照组相比，细菌感染组血清CRP明显升高，PA则明显降低，均有显著性差异，P〈0．05；感染危重组与非危重组结果比较，血清CRP亦明显升高，PA明显降低，两组间有显著性差异，P〈0．05；感染组治疗前与治疗后第2天、治疗后第2天与第7天比较，血清CRP有明显降低，PA明显升高，其差异均有显著性，P〈0．05，而治疗后第7天检测结果与对照组无显著性差异，P〉0．05。结论血清CRP及PA不仅可以作为诊断新生儿细菌感染的灵敏指标，还可用来评估感染的危重程度，同时，动态观察其血清水平还可用来评价感染性疾病的疗效。

Application value of detecting serum C-creative protein and prealbumin in neonatal bacterial infective diseases

Objective To evaluate the clinical values of serum C-reactive protein(CRP)and prealbumin(PA)in diagnosing,assessing the severity,and judging the therapeutic effects in neonatal infective diseases.Methods Serum levels of CRP and PA in 78 bacterial infective newborns were determined before and at days 2,7 after treatment by immunoturbidimetry.And serum CRP and PA in 59 healthy full-term newborns were also detected.Results Compared with the control group,the serum levels of CRP were much higher,but PA much lower in bacterial infective group.The difference was significant,P<0.05.The CRP and PA levels of severe infective newborns and non-severe newborns were significant different,P<0.05.The difference of CRP and PA before and at days 2,7 after treatment were also significant.There was no difference at day 7 after treatment compared with control group,P>0.05.Conclusion The serum CRP and PA are sensitive indexes for diagnosing neonatal bacterial infective diseases and assessing the severity.Meanwhile,the changes are helpful for judging the effect.