| 仙灵骨葆相关肝损伤的临床病例分析及拆方实验研究 |
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| 引用本文： | 黄迎,刘亚蕾,马润然,李春雨,马致洁,景婧,高源,沈鹏,林鸿波,郭玉明,柏兆方,肖小河,王伽伯. 仙灵骨葆相关肝损伤的临床病例分析及拆方实验研究[J]. 药学学报, 2021, 0(1): 266-273 |
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| 作者姓名： | 黄迎 刘亚蕾 马润然 李春雨 马致洁 景婧 高源 沈鹏 林鸿波 郭玉明 柏兆方 肖小河 王伽伯 |
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| 作者单位： | 湖南中医药大学药学院;中国人民解放军总医院第五医学中心;中国医学科学院肿瘤医院;首都医科大学附属北京友谊医院;首都医科大学中医药学院;宁波市鄞州区疾病预防控制中心 |
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| 基金项目： | 国家自然科学基金项目(81630100);国家重点研发计划项目(2018YFC1707002);解放军总医院科研专项(2019-JQPY-003)。 |
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| 摘 要： | 仙灵骨葆为骨科常用药,临床疗效好,但近年来发现有致肝损伤风险.本研究通过对文献不良反应报告和重点医院病例进行分析,发现文献检索到的仙灵骨葆肝损伤病例存在较大比例的报告信息不完整,难以准确判断其因果关系.重点医院药物性肝损伤(DILI)病例中,筛选出仙灵骨葆相关肝损伤患者6例,其中2例经整合证据链法评价达到了"临床诊断"...
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| 关 键 词： | 仙灵骨葆 整合证据链 免疫应激 淫羊藿 补骨脂 配伍减毒 |
Clinical case analysis and disassembled prescription study of liver injury related to Xianling Gubao |
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| HUANG Ying,LIU Ya-lei,MA Run-ran,LI Chun-yu,MA Zhi-jie,JING Jing,GAO Yuan,SHEN Peng,LIN Hong-bo,GUO Yu-ming,BAI Zhao-fang,XIAO Xiao-he,WANG Jia-bo. Clinical case analysis and disassembled prescription study of liver injury related to Xianling Gubao[J]. Acta pharmaceutica Sinica, 2021, 0(1): 266-273 |
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| Authors: | HUANG Ying LIU Ya-lei MA Run-ran LI Chun-yu MA Zhi-jie JING Jing GAO Yuan SHEN Peng LIN Hong-bo GUO Yu-ming BAI Zhao-fang XIAO Xiao-he WANG Jia-bo |
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| Affiliation: | (School of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China;China Military Institute of Chinese Medicine,the Fifth Medical Centre of Chinese PLA General Hospital,Beijing 100039,China;Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100039,China;Beijing Friendship Hospital,Capital Medical University,Beijing 100039,China;School of Traditional Chinese Medicine,Capital Medical University,Beijing 100039,China;Ningbo Yinzhou District Center for Disease Control and Prevention,Ningbo 315000,China) |
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| Abstract: | |
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| Keywords: | Xianling Gubao integrated evidence chain immune stress Epimedii Folium Psoraleae Fructus compatibility-mediated toxicity |
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