注射用甲磺酸酚妥拉明联合白眉蛇毒血凝酶治疗肺结核咯血的效果及对生活质量的影响

目的观察注射用甲磺酸酚妥拉明联合白眉蛇毒血凝酶治疗肺结核咯血的临床效果及对生活质量的影响。方法选取2019年1-12月惠州市第三人民医院收治的肺结核咯血患者70例为研究对象,按照患者入院奇偶顺序随机分为试验组和对照组,每组35例。在常规治疗基础上,对照组采用注射用甲磺酸酚妥拉明治疗,试验组在对照组基础上联合注射用白眉蛇毒血凝酶治疗,比较2组治疗效果、治疗后生活质量评分及药物不良反应。结果治疗1周后,试验组总有效率为97.14%,高于对照组的62.86%(χ²=12.857,P=0.000);治疗1周后,试验组心理功能、生理功能、健康状况、疼痛情况、生命力、情感功能、身体健康、社会功能均高于对照组(P<0.01);试验组不良反应发生率为5.71%,低于对照组的22.86%(χ²=4.200,P=0.040)。结论肺结核咯血患者给予注射用甲磺酸酚妥拉明联合白眉蛇毒血凝酶治疗效果显著,可明显提高患者生活质量,且治疗过程中药物不良反应发生率低,临床应用价值高。

Efficacy of phentolamine mesylate for injection combined with snake venom hemagglutinating enzyme in the treatment of tuberculosis hemoptysis and its influence on quality of life

Objective To analyze the clinical effect of combined treatment with phentolamine mesylate and snake venom hemocoagulase in patients with tuberculosis hemoptysis and its influence on quality of life.Methods 70 patients with tuberculosis hemoptysis admitted to the Third People's Hospital of Huizhou from January to December 2019 were selected as the research objects and randomly divided into the experimental group and the control group according to the odd and even order of admission,with 35 cases in each group.On the basis of conventional treatment,the control group was treated with phentolamine mesylate for injection,and the experimental group was treated with snake venom hemagglutinating enzyme for injection on the basis of the control group.The treatment effect,quality of life score and adverse drug reactions of the two groups were compared.Results After 1 week of treatment,the total effective rate of the experimental group was 97.14%,which was higher than the 62.86%of the control group(χ²=12.857,P=0.000).The experimental group's mental function,physical function,health status,pain condition,vitality,emotional function,physical health,and social function were all higher than those of the control group(P<0.01).The incidence of adverse reactions in the experimental group was 5.71%,which was lower than 22.86%in the control group(χ²=4.200,P=0.040).Conclusion The combined treatment of phentolamine mesylate and snake venom hemagglutinating enzyme in patients with tuberculous hemoptysis can significantly improve the treatment effect and quality of life.The probability of adverse drug reactions during the treatment of patients is lower.The clinical application value of this treatment method is significant and deserves further promotion use.