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Aminoindazole PDK1 Inhibitors: A Case Study in Fragment-Based Drug Discovery |
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| Authors: | Jesús R. Medina Charles W. Blackledge Dirk A. Heerding Nino Campobasso Paris Ward Jacques Briand Lois Wright Jeffrey M. Axten | |
| Affiliation: | †Oncology Research, Signal Transduction DPU Medicinal Chemistry;‡Molecular Discovery Research, Computational and Structural Chemistry;§Molecular Discovery Research, Analytical Chemistry;GlaxoSmithKline, Collegeville, Pennsylvania 19426;∥Molecular Discovery Research, Screening and Compound Profiling, GlaxoSmithKline, Research Triangle Park, North Carolina 27709 | |
| Abstract: | ||
| Keywords: | Aminoindazole PDK1 inhibitors fragment-based drug discovery ligand efficiency binding interactions | |