慢性心力衰竭患者躯体症状与心理状态的交叉滞后研究

  目的  采用交叉滞后回归分析模型探究慢性心力衰竭(chronic heart failure, CHF)患者躯体症状与心理状态之间的相互作用。  方法  选取2017年11月—2018年12月在山西省2家三甲医院心内科住院的262名慢性心衰患者，进行6个月的纵向追踪。采用心力衰竭患者报告结局调查问卷(patient-reported outcome measure for chronic heart failure, CHF-PROM)先后2次进行测量(T1和T2)，采用交叉滞后回归模型分析躯体症状和心理状态之间的关系。  结果  慢性心力衰竭患者躯体症状和心理状态均具有一定稳定性。2次测量的躯体症状和心理状态均成正相关(r=0.331, P < 0.001; r=0.445, P < 0.001)。交叉滞后回归分析显示，控制T1躯体症状后，T1心理状态可以预测T2躯体症状(β=0.163, P=0.010)；进一步分析心理状态各维度显示，控制T1躯体症状后，T1焦虑可以预测T2躯体症状(β=0.183, P=0.004)。  结论  心理状态是躯体症状的前因变量，心理状态可以正向预测躯体症状。进一步分析显示，焦虑是躯体症状的前因变量，焦虑对躯体症状具有正向预测作用。

A cross-lagged study of somatic symptoms and mental states in patients with chronic heart failure

Objective The cross-lagged regression model was used to investigate the interaction between somatic symptoms and mental states in patients with chronic heart failure(CHF).Methods A six-month longitudinal follow-up was conducted amongst 262 patients with chronic heart failure who were admitted to the Department of Cardiology of two of the top three hospitals in Shanxi Province from November 2017 to December 2018.The patient-reported outcomes instrument for CHF(patient-reported outcome measure for chronic heart failure,CHF-PROM)was used for two measurements(T1 and T2),Cross-lagged regression model was used to analyze the relationship between somatic symptoms and mental states.Results The physical symptoms and mental states of patients with chronic heart failure were stable.There was a positive correlation between physical symptoms and mental states(r=0.331,P<0.001;r=0.445,P<0.001).Cross-lagged regression analysis showed that after controlling for T1 somatic symptoms,T1 mental states could predict T2 somatic symptoms(β=0.163,P=0.010);Further analysis of the psychological state of each dimension showed that T1 anxiety predicted somatic symptoms of T2(β=0.183,P=0.004)after controlling for T1 somatic symptoms.Conclusions Mental states are the antecedents of somatic symptoms,which can positively predict somatic symptoms.Further analysis showed that anxiety is the antecedent variable of somatic symptoms and anxiety has a significant positive predictive effect on somatic symptoms.