纳米黑磷在光疗和药物载体方面的研究与应用

新兴的纳米黑磷材料为生物医学研究创造了新的平台,纳米黑磷具有以下优势:在近红外光照射下产生单线态氧,可作为光动力治疗的光敏剂;能够在较长的波长区域有广泛的光吸收,这种近红外光热特性可应用于光热治疗;黑磷纳米片具有较高的比表面积及独特的褶皱结构,这使其具有极高的载药量。本文主要围绕近年来黑磷在生物成像、光热治疗、光动力治疗和作为药物载体方面的应用进行了综述。黑磷纳米材料的光电特性结合智能给药平台,可以产生光/热/化学、光/化学/基因和光/化学/免疫协同治疗作用,具有广阔的应用前景。

Research and application of nanometer black phosphorus in phototherapy and drug carrier

The emerging nano-black phosphorus materials have created a new platform for biomedical research.Nano-black phosphorus has the following advantages:black phosphorus can produce singlet oxygen under near-infrared light irradiation,so it can be used as a photosensitizer for photodynamic therapy;black phosphorus has extensive light absorption in the long wavelength region,and this near-infrared photothermal property can be used in photothermal therapy.The high specific surface area and unique fold structure of the black phosphorus nanosheet make it have very high drug loading.This paper mainly reviews the applications of black phosphorus in biological imaging,photothermal therapy,photodynamic therapy,and as a drug carrier in recent years.Based on the photoelectric properties of black phosphorus nanomaterials combined with intelligent drug delivery platform,the synergistic effects of light/heat/chemistry,light/chemistry/gene,and light/chemistry/immunity can be produced,which has a broad application prospect.