Understanding the development and function of T follicular helper cells |
| |
Authors: | Roza I Nurieva Yeonseok Chung |
| |
Institution: | Department of Immunology, University of Texas MD Anderson
Cancer Center, Houston, TX, USA |
| |
Abstract: | A fundamental function of T helper (Th) cells is to regulate B-cell proliferation
and immunoglobulin class switching, especially in the germinal centers. Th1 and
Th2 lineages of CD4+ T cells have long been considered to play
an essential role in helping B cells by promoting the production immunoglobulin
G2a (IgG2a) and IgG1/IgE, respectively. Recently, it has become clear that a
subset CD4+ T cells, named T follicular helper (Tfh) cells, is
critical to B-cell response induction. In this review, we summarize the latest
advances in our understanding of the regulation of Tfh cell differentiation, the
relationship of Tfh cells to other CD4+ T-cell lineages, and the
role of Tfh cells in health and disease. |
| |
Keywords: | autoimmunity Bcl6 costimulation IL-21 T follicular helper (Tfh) cells |
|
|