外周血白细胞计数、C反应蛋白/白蛋白比值与动脉瘤性蛛网膜下腔出血患者短期预后相关性研究

目的 探讨外周血白细胞(WBC)计数、C反应蛋白/白蛋白(CRP/ALB)比值变化与动脉瘤性蛛网膜下腔出血(aSAH)患者短期预后的相关性.方法 选取自2018年1月至2020年6月收治的138例aSAH患者为研究对象,根据格拉斯哥预后量表(GOS)评分将患者分为预后良好组(n=101)与预后不良组(n=37),比较两...

Correlation between peripheral blood white blood cell count,C-reactive protein/albumin ratio and short-term prognosis in patients with aneurysmal subarachnoid hemorrhage

Objective To investigate the relationship between peripheral blood white blood cell(WBC)count,C-reactive protein/albumin(CRP/ALB)ratio and the prognosis of patients with aneurysmal subarachnoid hemorrhage(aSAH).Methods A retrospective study was performed on 138 cases of patients with aSAH who were admitted from January 2018 to June 2020.According to Glasgow outcome scale(GOS)score,the patients were divided into good prognosis group and poor prognosis group,and the clinical data of the two groups were compared.Multivariate Logistic regression was used to analyze the related factors affecting the prognosis of aSAH patients.Receiver operating characteristic(ROC)curve was used to analyze the value of WBC and CRP/ALB ratio in evaluating the short-term prognosis of aSAH patients.Results Among 138 aSAH patients,37 patients(26.8%)had poor prognosis and 101 patients(73.2%)had good prognosis.Univariate analysis showed that history of hypertension,Hung-hess grade,modified Fisher grade,aneurysm diameter,treatment approach,acute hydrocephalus,delayed cerebral ischemia(DCI),WBC and CRP/ALB ratio were related to prognosis of patients with aSAH(P<0.05).Multiariable Logistic regression analysis results showed that the history of high blood pressure,Hung-Hess classification(Ⅳ-Ⅴlevel),improved Fisher classification(Ⅲ-Ⅳlevel),peripheral blood WBC and elevated CRP/propagated ratio were the independent risk factors affecting the prognosis of patients with aSAH(P<0.05).The ROC curve results showed that the area under the curve of peripheral blood WBC for predicting poor prognosis in aSAH patients was 0.811,and the sensitivity and specificity were 0.733 and 0.762,respectively.The area under the curve of CRP/ALB ratio for predicting poor prognosis in aSAH patients was 0.806,and the sensitivity and specificity were 0.800 and 0.667,respectively.The area under the curve of the two combined tests for predicting adverse outcomes in patients with aSAH was 0.898,and the sensitivity and specificity were 0.867 and 0.859,respectively.Conclusion Peripheral blood WBC count and elevated CRP/ALB ratio are important risk factors for poor prognosis in patients with aSAH.Changes in the two levels help to predict the prognosis of aSAH patients.