1型糖尿病和2型糖尿病患者低血糖恐惧感和生活质量的比较研究

目的:比较1型糖尿病（T1DM）和2型糖尿病（T2DM）患者低血糖恐惧感和生活质量的差异。方法:采用多中心目的抽样方法选取2019年2至8月于天津市三家三级医院内分泌科就医的T1DM（21例）和T2DM（269例）患者作为研究对象，其中男156例（53.8%），女134例（46.2%），年龄（55.12±9.54）岁。...

A comparative study on the fear of hypoglycemia and quality of life in patients with type 1 and type 2 diabetes mellitus

Objective To investigate the difference of fear of hypoglycemia(FoH)and quality of life between patients with type 1 diabetes mellitus(T1DM)and type 2 diabetes mellitus(T2DM).Methods A total of 21 patients with T1DM and 269 patients with T2DM in Departments of Endocrinology from three tertiary hospitals in Tianjin from February to August,2019 were investigated by multicenter sampling.Among them,156 cases(53.8%)were males and 134 cases(46.2%)were females,with an average age of(55.12±9.54)years old.All the subjects were surveyed by the questionnaires including the general information questionnaire,the Chinese version of Hypoglycemia Fear SurveyⅡ-Worry Scale(CHFSⅡ-WS),the medical outcomes study item short Form health survey(SF-36),and the World Health Organization Five-item Well-Being Index(WHO-5).Kruskal-Wallis H test or Mann-Whitney U test was used for the measurement data,one-way analysis of variance(ANOVA)was used for comparison between groups.Chi-square test was used for statistical data.Multivariate linear regression was used for multivariate analysis.Results The differences of frequency and type of hypoglycemia between T1DM and T2DM patients were statistically significant(χ²=80.648,P<0.05;χ²=118.856,P<0.05).Scores of CHFSⅡ-WS,WHO-5,physiological function(PF),physical pain(BF),overall health(GH),social function(SF),emotional function(RE),mental health(MH),health change(HT)dimension of SF-36 were significantly different between patients with T1DM and T2DM(all P<0.05).There were significant differences in the scores of PF,SF and HT of CHFSII-WS and SF-36 among the diabetic patients with different types of hypoglycemia(all P<0.05).Multiple linear regression analysis showed that diabetes mellitus type,WHO-5 score,sex,mental health,regular examination and economic status were the independent influencing factors of FoH(partial regression coefficient was-1.621,0.027,0.407,-0.010,0.479,-0.226,all P<0.05).Conclusions The frequency,severity and fear level of FoH in T1DM patients are higher than those in T2DM patients.Hypoglycemia not only increases the fear level of hypoglycemia,but also affects the quality of life and mental health of patients.