单眼发病的原发性开角型青光眼黄斑脉络膜厚度及影响因素初探

目的:初步探讨原发性开角型青光眼（POAG）单眼发病患者黄斑中心凹下脉络膜厚度（SFCT）与其对侧眼和健康人的差异及其影响因素。方法:横断面研究。收集2018年9月至2019年9月就诊于首都医科大学附属北京同仁医院青光眼门诊确诊为POAG的单眼发病、对侧眼正常的患者（POAG组）以及健康志愿者（健康对照组）。对所有参与...

Sub-foveal choroidal thickness in both eyes of patients with unilateral primary open-angle glaucoma and related influencing factors

Objective To investigate and compare the sub-foveal choroidal thickness(SFCT)in both eyes of patients with unilateral primary open-angle glaucoma(POAG)and healthy controls.Methods Cross-sectional study.Patients with unilateral POAG and healthy controls were recruited from September 2018 to September 2019 in the Beijing Tongren Hospital.All subjects underwent enhanced depth imaging optical coherence tomography.The SFCT was measured at the fovea,and at 500μm,1000μm and 2000μm nasal and temporal to the fovea.Paired t test was conducted to compare the choroidal thickness between affected POAG eyes and unaffected fellow eyes.Analysis of covariance was conducted to compare the choroidal thicknesses between POAG eyes and controls.Multiple regression analysis determined the association between choroidal thickness and age,gender,spherical equivalent and mean deviation.Results Seventy-five patients with unilateral POAG(mean age,46 years;48 males,27 females)and 61 healthy controls(mean age,44 years;34 males,27 females)were included in this study.The SFCT of POAG eyes was(244.41±83.18)μm,which was not significantly different from their unaffected fellow eyes[(254.28±88.92)μm,P>0.05]and controls(right eyes)[(272.98±55.87)μm,P>0.05].Choroidal thickness at 2000μm nasal to the fovea was significantly decreased in the glaucomatous eyes compared with the unaffected fellow eyes[(167.84±70.44)vs.(188.84±89.06)μm,t=-3.55;P<0.01].There were no significant differences among the glaucomatous eyes,unaffected fellow eyes and healthy controls in choroidal thickness at 500μm and 1000μm nasal and temporal to the fovea,as well as at 2000μm temporal to the fovea(all P>0.05).The SFCT of POAG eyes was associated with mean deviation(β=14.66,P<0.05)and spherical equivalent(β=14.95,P<0.01)but not with age and gender(both P>0.05).Conclusions The SFCT of affected eyes in patients with unilateral POAG has no significant difference from unaffected fellow eyes and healthy controls.However,the choroidal thickness at 2000μm nasal to the fovea is thinner in the POAG eyes as compared with the fellow eyes.A thinner SFCT is correlated with the loss of visual field and a higher spherical equivalent in myopia.This may suggest a contributing role of the perfusion of the choroid in the pathogenesis of glaucoma.(Chin J Ophthalmol,2021,57:194-200)