基于脂质组学技术的中药降脂作用研究

高脂血症是一种常见的血脂异常疾病,是导致各种心血管疾病的重要危险因素.中药具有疗效确切、不良反应少、作用温和等优点,广泛应用于预防和治疗高脂血症.然而,由于中药成分复杂且作用靶点多,其降脂作用机制尚不明确.脂质组学作为研究生物系统中脂质及脂质相互作用的一门学科,能对不同生理病理状态下的脂质进行定性定量分析,寻找与中药降...

Research on the lipid-lowering effect of traditional Chinese medicine using lipidomics technology

Hyperlipidemia is a common disease with abnormal blood lipids and is an important risk factor for various cardiovascular diseases.Traditional Chinese medicine has the advantages of dependable lipid-lowering effects with few side effects and is widely used in the prevention and treatment of hyperlipidemia in China.However,due to the complex composition of traditional Chinese medicine and the many targets for treating hyperlipidemia,the mechanisms by which these medicines lower lipid levels are not well resolved.Lipidomics is a discipline that studies lipids and the interaction of lipids in biological systems.Lipidomics can identify and quantify the lipids in vivo under physiological and pathological conditions,helping to discover the potential biomarkers related to the lipid-lowering effects of traditional Chinese medicine and providing a basis for systematically studying the lipidlowering effect of traditional Chinese medicine.This review introduces the principal research methods used in lipidomics and summarizes the results and prospects of application of lipidomics in the research on the lipid-lowering effects of traditional Chinese medicine.