中国50岁及以上人群心脑血管疾病和认知功能的关联研究

  目的  探讨我国≥50岁人群心脑血管疾病与认知功能的关联。  方法  利用WHO全球老龄化与成人健康研究中国项目基线数据。认知功能测试包括即时、延时词语回忆、数字广度、语言流畅度。心脑血管疾病包括高血压、心绞痛和脑卒中。采用一般线性回归模型分析心脑血管疾病与认知功能的关联。  结果  共纳入12 645名调查对象。一般线性回归分析显示，与不患心脑血管疾病者相比，只患心绞痛者即时、延时词语回忆和整体认知得分均更低(均有P < 0.05)，共患高血压和心绞痛者每项认知得分均更低(均有P < 0.05)，共患高血压和脑卒中者即时、延时词语回忆、数字广度测试和整体认知得分更低(均有P < 0.05)，共患心绞痛和脑卒中者数字广度测试和整体认知得分均更低(均有P < 0.05)，共患高血压、心绞痛和脑卒中者数字广度测试得分更低(P=0.019)。心脑血管疾病患病数量与每项认知得分均呈负相关(均有P < 0.05)。  结论  与不患心脑血管疾病者相比，共患心脑血管疾病与更差的认知功能相关。

Association between cardiovascular and cerebrovascular diseases and cognition among Chinese aged 50 years and older

Objective To investigate the association between cardiovascular and cerebrovascular diseases and cognition among Chinese aged 50 and over.Methods Data was collected from the World Health Organization study on global ageing and adult health wave in China.A comprehensive battery of cognitive tests was conducted to assess subjects'cognitive functions,including immediate and delayed verbal recall,digit span and verbal fluency.Cardiovascular and cerebrovascular diseases included hypertension,angina and stroke.General linear model was used to examine the association of cardiovascular and cerebrovascular diseases with cognition.Results A total of 12645 adults aged 50 and over who did cognitive tests and without obvious cognitive impairment were selected as participants.Compared with people without cardiovascular and cerebrovascular diseases,people who only had angina had lower scores in immediate and delayed verbal recall and composite cognition(all P<0.05).Participants who had both hypertension and angina had lower scores in immediate and delayed verbal recall,digit span,verbal fluency and composite cognition(all P<0.05).Participants who had both hypertension and stroke had lower scores in immediate and delayed verbal recall,digit span and composite cognition(all P<0.05).Participants who had both angina and stroke had lower scores in digit span and composite cognition(all P<0.05).Participants who had all of hypertension,angina and stroke had lower score in digit span(P=0.019).The number of cardiovascular and cerebrovascular diseases was negatively associated with immediate and delayed verbal recall,digit span,verbal fluency and composite cognition(all P<0.05).Conclusions Comorbid cardiovascular and cerebrovascular diseases were associated with worse cognitive function.