纳米药物肿瘤聚集性和渗透性的主要进展

纳米药物在肿瘤治疗中有巨大的潜力,但复杂的肿瘤微环境给纳米药物向肿瘤的递送带来了很多障碍。纳米药物从入血到在肿瘤中发挥作用,需要经历循环、聚集、渗透、内化和释放5个步骤,其中聚集和渗透环节更重要。本文综述了纳米药物在提高肿瘤聚集性和渗透性方面的新进展,尤其是近5年出现或发展的技术手段。

Major progress in tumor accumulation and penetration of nanomedicine

Nanomedicine has great potential in cancer therapy,but the complex tumor microenvironment greatly prevents nanomedicine from being effectively delivered into tumor in vivo.It has been widely accepted that the encapsulated drugs in the nanoparticles have to go through five major cascading steps,including blood circula‐tion,accumulation in tumor,penetration into the depth of tumor tissue,internalization by tumor cells and then intra‐cellular drug release,before they can exert the anti-tumor efficacy.Among the five steps,drug accumulation in tumor and penetration in the depth of tumor have been the two major issues undermines the antitumor efficacy of nanomedicine.This paper summarizes the new major progress in improving the tumor accumulation and penetra‐tion of nanomedicine,especially the technologies that appeared or developed in the last five years.