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顺铂联合白介素-2治疗恶性胸腔积液疗效观察
引用本文:朱早君.顺铂联合白介素-2治疗恶性胸腔积液疗效观察[J].中国实用医药,2008,3(32):27-28.
作者姓名:朱早君
作者单位:河南省安阳市安阳钢铁集团公司职工总医院,455004
摘    要:目的观察顺铂联合白介素-2胸腔灌注治疗恶性胸腔积液的临床疗效和毒副反应。方法采用胸腔闭式引流术,观察组在胸腔内注入顺铂60mg、白介素-2100万U,对照组在胸腔内注入顺铂60mg。每周1次,共1~3次。观察疗效、生活质量、生存率和毒副反应。结果观察组有效率为81.82%,照组有效率为55.00%,差异有显著性(P〈0.05)。两组无严重不良反应,均可耐受。结论顺铂和白介素-2联合胸腔内注射,消除胸水作用明显,值得临床推广。

关 键 词:顺铂  白介素-2  恶性胸腔积液

Therapeutic effects of thoracic cavity of cisplatin and interleukin-2 in maligant pleural effusion
Zhu zao-jun.Therapeutic effects of thoracic cavity of cisplatin and interleukin-2 in maligant pleural effusion[J].China Practical Medical,2008,3(32):27-28.
Authors:Zhu zao-jun
Institution:Zhu zao-jun Henan Anyang iron and steel group staff general Hospital Anyang 455004,China
Abstract:Objective To evaluate the therapeutic effect and side effect of thoracic cavity injection of eisplatin and interleukin-2 in maligant pleural effusion. Methods In theray group ,25 cases with maligant pleural effusion, after chest drainage, were injected into pleural cavity with interleukin-2 one millionaire unit and cisplatin 60 mg weekly for I -3 weeks, and in control group,22 cases were injected only with eisplatin 60 mg weekly for 1 - 3 weeks. The efficacy, quality of life, relapse rate and toxicities were evaluated. Results The response rate after 6 months in treatment group was lower than that in the control group (P 〈 0.05 ). The toxicities of two groups were tolerated. Conclusion The thoracic cavity injection of cisplatin and interleukin-2 in maligant pleural effusion is an effective way and worth in clnieal application.
Keywords:Cisplatin  Interleukin-2  Maligant pleural effusion
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