顺铂联合白介素-2治疗恶性胸腔积液疗效观察

目的观察顺铂联合白介素-2胸腔灌注治疗恶性胸腔积液的临床疗效和毒副反应。方法采用胸腔闭式引流术,观察组在胸腔内注入顺铂60mg、白介素-2100万U,对照组在胸腔内注入顺铂60mg。每周1次,共1～3次。观察疗效、生活质量、生存率和毒副反应。结果观察组有效率为81.82%,照组有效率为55.00%,差异有显著性（P〈0.05）。两组无严重不良反应,均可耐受。结论顺铂和白介素-2联合胸腔内注射,消除胸水作用明显,值得临床推广。

Therapeutic effects of thoracic cavity of cisplatin and interleukin-2 in maligant pleural effusion

Objective To evaluate the therapeutic effect and side effect of thoracic cavity injection of eisplatin and interleukin-2 in maligant pleural effusion. Methods In theray group ,25 cases with maligant pleural effusion, after chest drainage, were injected into pleural cavity with interleukin-2 one millionaire unit and cisplatin 60 mg weekly for I -3 weeks, and in control group,22 cases were injected only with eisplatin 60 mg weekly for 1 - 3 weeks. The efficacy, quality of life, relapse rate and toxicities were evaluated. Results The response rate after 6 months in treatment group was lower than that in the control group （P 〈 0.05 ）. The toxicities of two groups were tolerated. Conclusion The thoracic cavity injection of cisplatin and interleukin-2 in maligant pleural effusion is an effective way and worth in clnieal application.