Characterization of Mount Elgon bat virus, a new member of the rhabdovirus group |
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| Authors: | F A Murphy R E Shope D Metselaar D I Simpson |
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| Affiliation: | 1. U.S. Department of Health, Education, and Welfare, Public Health Service, Health Services and Mental Health Administration, National Communicable Disease Center, Atlanta, Georgia 30333 USA;2. Yale University School of Medicine, New Haven, Connecticut, USA;3. Netherlands Medical Research Centre, Nairobi, Kenya;4. Department of the Royal Tropical Institute of Amsterdam Netherlands;5. Microbiological Research Establishment, Porton Down, Wiltshire, England;1. Department of Medical Genetics, University of Alberta, Edmonton, Alberta, Canada;2. Department of Cell Biology, University of Alberta, Edmonton, Alberta, Canada;1. Department of Virology 3, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan;2. Virus Unit, School of Veterinary Medicine, Rakuno Gakuen University, 582 Midorimachi, Bunkyodai, Ebetsu, Hokkaido 069-8501, Japan;3. Research and Education center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan;4. Laboratory of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan;5. Hikiiwa Park Center, 1629 Inari-cho, Tanabe 646-0051, Japan;6. Department of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University, 582 Midorimachi, Bunkyodai, Ebetsu-shi 069-8501, Japan;7. Department of Pathology, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan;8. Department of Virology 1, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan;9. Department of Veterinary Science, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 162-8640, Japan;1. Department of Infectious Diseases, University of Georgia, Athens, GA, 30602, USA;2. Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, 30602, USA;3. Institute for Bioinformatics, University of Georgia, Athens, GA, 30602, USA;1. Health Protection Scotland, Glasgow, UK;2. NHS Greater Glasgow & Clyde, Glasgow, UK;3. University of Glasgow, Glasgow, UK |
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| Abstract: | Mount Elgon Bat (MEB) virus, an isolate from a Rhinolophus hildebrandtii eloquens (K. Anderson) bat from Kenya, was examined by negative contrast and thin-section electron microscopy. It was found in infected mouse brain tissue to be bullet-shaped with structural details similar to other viruses of the Rhabdovirus group. Virus particles had a mean length of 226 nm and were 68 nm in diameter. The internal helically wound cylinder consisted of a single strand approximately 10 nm in diameter. In mouse brain, virus maturation occurred upon plasma membranes; viral matrix or inclusion material was in many cases located in the cytoplasm beneath sites of viral budding. The matrix consisted of convoluted filaments or strands. Complement-fixation, neutralization, and immunodiffusion tests comparing MEB virus with all the known Rhabdoviruses of animals failed to show any cross-reactivity. The described characteristics form the basis for considering MEB as an antigenically distinct member of the Rhabdovirus group. |
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