血管内皮生长因子在肺动脉平滑肌细胞重构中的作用

目的 :探讨血管内皮生长因子 （VEGF）在野百合碱 （MCT）性肺动脉高压 （PH）中的作用。方法 :用 MCT复制大鼠慢性 PH病理模型 ,用免疫组化法和图像分析技术测定肺组织中 VEGF的表达。结果 :发现 VEGF可在正常大鼠肺血管平滑肌、支气管平滑肌和软骨组织中表达 ,并且 MCT组 VEGF表达的相对含量在肺血管平滑肌 （177±7）和支气管平滑肌 （172± 6）均较正常组 （血管平滑肌 13 6± 8,支气管平滑肌 13 8± 12 ）呈显著增强 （P<0 .0 5）。结论 :MCT性 PH中 VEGF在肺血管平滑肌的过度表达参与 MCT性 PH的发病过程

The role of vascular endothelial growth factor in monocrotaline-induced pulmonary hypertension

AIM: To explore the role of vascular endothelial growt h factor(VEGF ) in monocrotaline-induced pulmonary hypertension. METHODS: VEGF was investigat ed by using immunohistochemistry and image analysis on the chronic pulmonary hyp ertension (PH) induced by MCT in Sprague-Dawley rats. RESULTS: VE GF was positive in pulmonary vascular smooth muscle cells, bronchial smooth muscle cells and ch ondrocytes in the control group. VEGF in the MCT group was more prominent in pu lmonary vascular smooth muscle cells and bronchial smooth muscle cells as compar ed with the control. CONCLUSION: Over expression of VEGF in pulmonary vascular smoo th muscle cells and bronchial smooth muscle cells is related to MCT-induced PH.