Short-term oxygen administration restores blunted baroreflex sensitivity in patients with type 1 diabetes |
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| Authors: | Bernardi L,Rosengård-Bärlund M,Sandelin A,Mäkinen V P,Forsblom C,Groop P-H FinnDiane Study Group |
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| Affiliation: | (1) Folkh?lsan Institute of Genetics, Folkh?lsan Research Center, University of Helsinki, Helsinki, Finland;(2) Department of Internal Medicine, IRCCS San Matteo - University of Pavia, Pavia, Italy;(3) Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, Helsinki, Finland;(4) The Baker IDI Heart and Diabetes Institute, Melbourne, VIC, Australia;(5) Folkh?lsan Research Center, Biomedicum Helsinki (C318b), University of Helsinki, PO Box 63, FIN-00014 Helsinki, Finland; |
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| Abstract: | Aims/hypothesis We hypothesised that the blunted baroreflex sensitivity (BRS) typical of type 1 diabetes is caused by a higher degree of tissue hypoxia in diabetes, and tested whether oxygen increased BRS and ventilation less, equally or more than in healthy control participants (the latter suggesting higher tissue hypoxia). In addition, we also considered the possible interference between oxygen and breathing pattern. |
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