原发性食管胃交界处恶性黑色素瘤1例及文献复习

目的 分析原发性食管恶性黑色素瘤的临床病理学特征。方 法对1例原发性食管胃交界处恶性黑色素瘤进行组织学观察和免疫组化标记，同时复习相关文献。结果原发性食管胃交界处恶性黑色素瘤的组织学改变类似于皮肤发生的恶性黑色素瘤。免疫表型：肿瘤细胞HMB45、S-100蛋白和vimentin阳性，cytokeratin阴性。同时必须排除皮肤、眼等处的原发病灶。结论 原发性食管胃交界处恶性黑色素瘤(无色素性)是一种罕见的肿瘤，应该与一些食管发生的肿瘤相鉴别如低分化癌、肉瘤和转移性恶性黑色素瘤等。本瘤预后极差，术后平均生存时间仅为10个月。

Primary malignant melanoma of oesophagogastric junction:a case report and review of literature

Purpose To analyze the clinical pathological features of primary malignant melanoma in the oesophagus. Methods A case of primary malignant melanoma at the esophagogastric junction was described and related literature was reviewed. Results The histological apperance of primary malignant melanoma in the oesophagus was similar to that of the skin counterparts. Immunohistochemical staining for HMB-45, S-100, and vimentin was positive, and negative for cytokeratin in the tumor cells. Neither primary tumors nor metastases were detected in the whole body search (skin, eyes, rectum, etc). Conclusions Primary malignant melanoma at the esophagogastric junction is extremely rare. It should be differentiated from oesophageal tumors, including low differential squamous cell carcinoma, sarcoma and metastatic malignant melanoma. Malignant melanoma had a poor prognosis.