鸦胆子油乳介入治疗膀胱肿瘤的动物实验研究

目的 探讨鸦胆子油乳介入治疗膀胱肿瘤的作用机理。方法 以Ｎ－甲基亚硝基脲（ＭＮＵ）为诱癌剂，特异性诱发大鼠膀胱肿瘤。以光镜、扫描电镜、透射电镜等观察髂内动脉介入鸦胆子油乳及以明胶微球为栓塞剂治疗膀胱肿瘤的效果。结果 ＭＮＵ诱导膀胱肿瘤率１００．０％，鸦胆子油介入组发癌率６０．０％，介入加栓塞组发癌率２６．６％，三组间差别有显著性意义（Ｐ〈０．００５）。结论 鸦胆子油乳介入或加栓塞剂对ＭＮＵ诱导的大

Intra-arterial infusion of bruceatin seed oil emulsion for bladder tumor induced by MNU in rats

Objective To study intra arterial infusion of bruceatin seed oil emulsion in treating bladder tumor in rats induced by N methy N nitrosourea(MNU). Methods Bladder tumors were induced in female Wistar rats by intravesical administration of MNU.Emulsion of seed oil of bruceatin was infused into the internal iliac artery on both sides for the treatment of the bladder tumors.The morphological alterations of the bladder epithelial cells were studied by light microscopy,scanning and transmission electron microscopy. The rats were randomized into the induced tumor group (group A),untreated group (group B) bruceatin treated group (group C) and the bruceatin treated together with embolization group (group D). Results The incidence of bladder tumor in group A was 100.0%,in group C 60.0% and in group D 26.6%.The difference between A and C,D has been significant ( P <0.005). Conclusions Bilateral intra arterial infusion (internal iliac artery) either with or without embolization is effective in treating bladder tumor induced by MNU in rats.