Effect of a prepregnancy pertussis booster dose on maternal antibody titers in young infants |
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| Authors: | Leuridan Elke Hens Niel Peeters Natasja de Witte Liene Van der Meeren Olivier Van Damme Pierre |
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| Affiliation: | Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, WHO Collaborating Centre for Control and Prevention of Infectious Diseases, Faculty of Medicine, University of Antwerp, Antwerp, Belgium. Elke.leuridan@ua.ac.be |
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| Abstract: | To examine the influence of a pertussis booster vaccination on the transfer of maternal antibodies, 24 nonpregnant women received a tetanus, diphtheria, acellular pertussis booster vaccine between 2 consecutive pregnancies. Blood was drawn from mothers and off-spring. Efficient transplacental antibody transfer and significantly higher antibody titers against 3 pertussis antigens were observed in cord blood and in blood of 1-month-old infants born after a maternal booster vaccination compared with results in their siblings born before the booster administration. |
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