| 低剂量奥氮平治疗老年慢性失眠症的临床观察 |
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| 引用本文： | 李卫公,阳燕,温秀兰. 低剂量奥氮平治疗老年慢性失眠症的临床观察[J]. 现代医药卫生, 2011, 27(17): 2590-2592 |
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| 作者姓名： | 李卫公 阳燕 温秀兰 |
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| 作者单位： | 江油市人民医院神经内科,四川江油,621700 |
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| 摘 要： | 目的:探讨对老年慢性失眠症的有效治疗方法.方法:用随机对照方法,将120例老年慢性失眠症患者按随机数字表法分为奥氮平组和阿普唑仑组,治疗4周.采用匹兹堡睡眠质量指数(pittsburgh sleep quality index,PSQI)及药物不良反应量表评定临床疗效和不良反应.结果:奥氮平组在治疗第四周时PSQI总分、汉密顿焦虑量表(Hamilton anxiety scale,HAMA)、汉密顿抑郁量表(Hamilton depression raling scale,HAMD)、临床显效率分别为(5.2±1.8)分、(11.5±5.4)分、(5.1±2.3)分、91.7％,明显优于阿普唑仑组(6.8±2.5)分、(17.5±7.8)分、(9.9±5.8)分、68.3％,差异具有显著性(P＜0.05).结论:低剂量奥氮平不仅能显著改善慢性失眠症患者的睡眠状况,而且可以明显减少患者日常功能的缺失.
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| 关 键 词： | 老年慢性失眠症 奥氮平 阿普唑仑 匹兹堡睡眠质量指数 |
Clinical observation of low-dose olanzapine in treating elderly chronic insomnia |
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| LI Wei-gong , YANG Yan , WEN Xiu-lan. Clinical observation of low-dose olanzapine in treating elderly chronic insomnia[J]. JOURNAL OF MODERN MEDICINE & HEALTH, 2011, 27(17): 2590-2592 |
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| Authors: | LI Wei-gong YANG Yan WEN Xiu-lan |
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| Affiliation: | LI Wei-gong,YANG Yan,WEN Xiu-lan(Department of Neurology,Jiangyou People's Hospital,Jiangyou,Sichuan 621700,China) |
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| Abstract: | Objective:To study the effective treatment of elderly chronic insomnia.Methods:Using randomized controlled methods,120 cases of elderly chronic insomnia were randomly divided into olanzapine group and alprazolam group.The Pittsburgh Sleep Quality Index(PSQI) and drug side-effects scale were adopted to evaluate the clinical efficacy and adverse reactions after 4-week treatment.Results:The PSQI total score,Hamilton Anxiety Scale(HAMD),Hamilton Depression Rating Scale(HAMA) and the clinical excellent effective... |
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| Keywords: | Elderly chronic insomnia Olanzapine Alprazolam Pittsburgh Sleep Quality Index |
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